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首页> 外文期刊>The Canadian journal of hospital pharmacy. >Physicochemical Stability of Vancomycin at High Concentrations in Polypropylene Syringes
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Physicochemical Stability of Vancomycin at High Concentrations in Polypropylene Syringes

机译：聚丙烯注射器高浓度下万古霉素的物理化学稳定性

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Background: In severe infections, high-concentration vancomycin may be administered by continuous infusion. The dosage of vancomycin may reach 60 mg/kg per day. Objectives: To study the feasibility of preparing high-concentration vancomycin solutions (40 to 83.3 mg/mL), to study the effect of an electric syringe pump on the physical stability of high-concentration vancomycin, and to study the stability of vancomycin 62.5 and 83.3 mg/mL in 0.9% sodium chloride (0.9% NaCl) or 5% dextrose in water (D5W) with storage up to 48 h at room temperature. Methods: The following sets of syringes were prepared: (1)4 syringes of vancomycin in 0.9% NaCl for each of 5 concentrations between 40 and 83.3 mg/mL (total 20 syringes); (2) 6 syringes at 83.3 mg/mL in 0.9% NaCl and 6 syringes at 83.3 mg/mL in D5W; and (3) 30 syringes at 83.3 mg/mL in D5W. Visual inspection was performed for all 3 syringe sets, and subvisual inspection for sets 1 and 2 (for periods of 24 h for set 1 and 48 h for sets 2 and 3). One syringe of vancomycin 83.3 mg/mL with each solvent was inserted into an electric syringe pump, and samples from the infusion line and collected after transit through the pump were inspected visually. Chemical stability was evaluated by high-performance liquid chromatography, and physical stability, pH, and osmolality were investigated. Results: For all sets of syringes, no physical modification was observed over time, nor were any changes observed after transit through the electric syringe pump. In 0.9% NaCl, vancomycin 62.5 and 83.3 mg/mL retained more than 90% of the initial concentration after 48 and 24 h, respectively; however, for the 83.3 mg/mL solution, precipitate was visible after 48 h. In D5W, vancomycin at 62.5 and 83.3 mg/mL retained more than 90% of the initial concentration after 48 h. Conclusion: It was feasible to prepare high-concentration solutions of vancomycin. The electric syringe pump did not cause any precipitation. Vancomycin in D5W at 62.5 and 83.3 mg/mL was stable over 48 h at room temperature. Precipitation occurred in 0.9% NaCl. D5W is therefore recommended as the solvent for this drug.
机译：背景：在严重的感染中，可以通过连续输注来施用高浓度万古霉素。万古霉素的剂量每天可达到60mg / kg。目的：研究制备高浓度万古霉素溶液（40至83.3mg / ml）的可行性，研究电动注射器泵对高浓度万古霉素物理稳定性的影响，研究万古霉素62.5和稳定性在0.9％氯化钠（0.9％NaCl）中的83.3mg / ml或在水（D5W）中的5％葡萄糖，室温高达48小时。方法：制备以下一组注射器：（1）40％NaCl的Vancomycin的4个注射器，每个浓度为40-83.3mg / ml（总共20个注射器）; （2）6在0.9％NaCl中的83.3mg / ml的6个注射器，在D5W中为83.3mg / ml。 （3）在D5W中以83.3mg / ml的30个注射器。对所有3个注射器组进行了目视检查，以及用于组1和2的副检查（对于设置1和48小时的24小时，设置2和3）。将每种溶剂插入电气注射器泵中的万古霉素83.3mg / ml的一个注射器，并在视觉上检查来自输注线并通过泵运输后收集的样品。通过高效液相色谱评价化学稳定性，研究了物理稳定性，pH和渗透压。结果：对于所有的注射器，随着时间的推移没有观察到物理修改，在通过电气注射器泵的运输后观察到的任何变化也不会发生任何变化。在0.9％NaCl，万古霉素62.5和83.3mg / ml分别在48和24小时后保留超过90％的初始浓度;但是，对于83.3mg / ml溶液，48小时后沉淀物可见。在D5W，62.5和83.3mg / ml的万古霉素在48小时后保留超过90％的初始浓度。结论：制备万古霉素的高浓度溶液是可行的。电动注射器泵不会引起任何沉淀。在62.5和83.3mg / ml的D5w中的万古霉素在室温下在48小时内稳定。沉淀在0.9％NaCl中发生。因此，推荐D5W作为该药物的溶剂。

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