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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Prognostic Value of Serum D-Dimer in Noncardioembolic Ischemic Stroke
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Prognostic Value of Serum D-Dimer in Noncardioembolic Ischemic Stroke

机译：血清D-二聚体在非连杆缺血性卒中的预后价值

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Background: Although D-dimer levels are significantly associated with cardioembolic infarction, the significance of D-dimer levels in relation to the severity and functional outcomes of other stroke subtypes, such as lacunar and large artery atherosclerosis infarction, remains unclear. The purpose of this study was to evaluate whether elevated initial D-dimer levels are significantly and cross-sectionally associated with poor functional outcomes at each time point during a 9-month follow-up period. We also investigated the significance of D-dimer levels in longitudinal temporal changes of functional outcomes in these patients. Methods: We recruited 146 patients with lacunar infarction and 161 patients with large artery atherosclerosis infarction who were consecutively admitted to our hospital after acute stroke. Serum D-dimer levels were evaluated initially and the modified Rankin scale were measured initially and at 1-, 3-, 6-, and 9-month follow-up visits. Results: Patients with higher D-dimer levels had significantly worse initial functional outcomes, and these worse outcomes were maintained throughout the 9-month follow-up period compared with the low D-dimer group. However, regardless of stroke subtype, D-dimer levels did not influence long-term changes in functional outcomes over the 9-month follow-up period. Conclusion: This study suggests that elevated D-dimer levels can be used as a surrogate marker for poor functional outcomes only during the acute stage. Further evaluation of serum D-dimer levels could provide a helpful predictive marker for stroke prognosis.
机译：背景：虽然D-二聚体水平与心脏栓塞梗死有显着相关，但是D-二聚体水平与其他中风亚型的严重程度和功能结果相关的意义仍不清楚。本研究的目的是评估升高的初始D-二聚体水平是否有显着和横截面与9个月的随访期间每次点的功能性差异差。我们还研究了这些患者功能性结果的纵向时间变化中D-二聚体水平的重要性。方法：我们招募了146例患有型梗死梗死梗死的患者，161例大动脉动脉粥样硬化梗死症，急性中风后连续入院。最初评估血清D-二聚体水平，并且最初测量改性的Rankin规模，并在1-，3-，6-和9个月的后续访问中进行测量。结果：D-二聚体水平较高的患者初始初始功能性结果显着较差，与低D-二聚体组相比，在整个9个月的随访期间维持这些更差的结果。然而，无论中风亚型如何，D-二聚体水平在9个月的随访期内没有影响功能结果的长期变化。结论：本研究表明，仅在急性阶段，升高的D-二聚体水平可用作替代官能结果的替代标志物。进一步评价血清D-二聚体水平可以为中风预后提供有用的预测标志物。

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