• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Refractory Epilepsy: The Role of Positron Emission Tomography
【24h】

Refractory Epilepsy: The Role of Positron Emission Tomography

机译：难治性癫痫：正电子发射断层扫描的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Rationale: Presurgical localization of the epileptogenic focus is critical to successful surgery. Traditionally, localization of the epileptogenic focus depends on seizure semiology, scalp video-electroencephalography (vEEG), magnetic resonance imaging (MRI), neuropsychological assessment, and, when needed, intracranial EEG (iEEG). We aimed to explore the role of positron emission tomography (PET) in the presurgical evaluation of patients with refractory epilepsy. Methods: A retrospective review was conducted on patients from London Health Sciences Centre (London, Ontario) with refractory epilepsy who underwent PET from September of 2011 to April of 2016. The accuracy of epileptogenic focus localization was compared between different investigative modalities (MRI, vEEG, iEEG, PET), and the outcomes were documented, including seizure freedom after surgical resection, improvement of seizure frequency, guidance for further investigations, and exclusion of patients from further evaluation. Patients who underwent surgery were followed up at 3 months and onward. Results: We identified 62 patients with refractory epilepsy who underwent PET. The mean age was 34 years (range=20-68). A total of 36 had concordant PET and vEEG findings: 6 had surgical resection and either became seizure-free (29.4%) or had improvement in seizure frequency (5.9%) at 3 months; 11 had surgical resection and either became seizure-free (29.4%) or had improvement in seizure frequency (35.3%) at 3 months, but required iEEG for final verification. Conclusions: PET has an important role in presurgical evaluation of patients with refractory epilepsy. It may allow resection of the epileptogenic focus without the need for iEEG, guiding intracranial electrode placement for further localization of the epileptogenic focus, or exclusion of patients from further evaluation.
机译：理由：癫痫症焦点的配前本地化对成功手术至关重要。传统上，癫痫焦点的定位取决于癫痫发作术，头皮视频脑电图（VEEG），磁共振成像（MRI），神经心理学评估，并且在需要时，颅内脑脑脑脑脑内（IEEG）。我们旨在探讨正电子发射断层扫描（PET）在难治性癫痫患者的配备评价中的作用。方法：对来自伦敦健康科学中心（伦敦，安大略省）的患者进行了回顾性审查，难治性癫痫于2011年9月至2016年4月接受了宠物。在不同的调查模式（MRI，VEEG）之间比较了癫痫焦点定位的准确性，IEEG，PET）和结果被记录，包括手术切除后的癫痫发作自由，改善癫痫发作，进一步调查的指导，以及排除患者从进一步评估。接受手术的患者随访3个月和向前。结果：我们鉴定了62例患有宠物的难治性癫痫患者。平均年龄为34岁（范围= 20-68）。共有36种有效的宠物和veeg结果：6有手术切除，无论是无癫痫发作（29.4％）或3个月内的癫痫发作（5.9％）是否有所改善; 11具有手术切除，无论是无癫痫发作（29.4％）还是在3个月内有癫痫发作（35.3％），但需要IEEG进行最终核查。结论：宠物在难治性癫痫患者的预设评估中具有重要作用。它可以允许切除癫痫胚胎的焦点而不需要引导颅内电极放置以进一步定位癫痫焦点，或者从进一步评估中排除患者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号