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首页> 外文期刊>The Journal of Chemical Thermodynamics >Solubility of L-tyrosine in aqueous solutions of methanol, ethanol, n-propanol and dimethyl sulfoxide: Experimental determination and preferential solvation analysis
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Solubility of L-tyrosine in aqueous solutions of methanol, ethanol, n-propanol and dimethyl sulfoxide: Experimental determination and preferential solvation analysis

机译：L-酪氨酸在甲醇，乙醇，正丙醇和二甲基亚甲醚水溶液中的溶解度：实验测定和优先溶剂化分析

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摘要

The equilibrium solubility of L-tyrosine in solvent mixtures of methanol (1) + water (2), ethanol (1) + water (2), n-propanol (1) + water (2) and dimethyl sulfoxide (DMSO, 1) + water (2) were determined experimentally by using isothermal dissolution equilibrium method within the temperature range from 283.15 to 323.15 K under atmospheric pressure (101.1 kPa). At the same temperature and mass fraction of methanol (ethanol, n-propanol or DMSO), the mole fraction solubility of L-tyrosine was greater in (DMSO + water) than in the other three solvent mixtures. The solvent effect was explained in terms of solute-solvent and solvent-solvent interactions. The preferential solvation parameters were derived from their thermodynamic solution properties by means of the inverse Kirkwood-Buff integrals method. The preferential solvation parameters (delta chi(1,3)) for methanol, ethanol, n-propanol or DMSO were negative in the methanol (1) + water (2), ethanol (1) + water (2), n-propanol (1) + water (2) mixtures with a very wide compositions, which indicated that L-tyrosine was preferentially solvated by water. While L-tyrosine was preferentially solvated neither by water nor by DMSO for the DMSO (1) + water (2) mixtures. Temperature has a little effect on the preferential solvation magnitudes for the studied solutions. The higher solvation by water could be explained in terms of the higher acidic behavior of the solvent interacting with the Lewis basic groups of the L-tyrosine. In addition, the drugs' solubility was mathematically represented by using the Jouyban-Acree model, van't Hoff-Jouyban-Acree model and Apelblat-Jouyban-Acree model obtaining average relative deviations lower than 1.47% for correlative studies. It is noteworthy that the solubility data presented in this work contribute to the expansion of the physicochemical information about the solubility of drugs in binary solvent mixtures and also allows the thermodynamic analysis of the respective dissolution and speci
机译：L-酪氨酸在甲醇（1）+水（2），乙醇（1）+水（2），正丙醇（1）+水（2）和二甲基亚砜（DMSO，1）中的溶剂混合物中L-酪氨酸的平衡溶解度通过在大气压（101.1kPa）下的温度范围内通过在283.15至323.15k的温度范围内通过实验确定水（2）。在相同的温度和质量分数的甲醇（乙醇，正丙醇或DMSO）中，L-酪氨酸的摩尔级分溶解度大于（DMSO +水）比其他三种溶剂混合物更大。就溶质 - 溶剂和溶剂 - 溶剂相互作用而言，解释了溶剂效应。优先的溶剂化参数通过逆kirkwood-buff积分法从其热力学溶液特性衍生出来。甲醇，乙醇，正丙醇或DMSO的优先溶剂化参数（Delta Chi（1,3））在甲醇（1）+水（2）中为阴性，乙醇（1）+水（2），N-丙醇（1）+水（2）具有非常宽的组合物的混合物，表明L-酪氨酸优先用水溶液。虽然L-酪氨酸既不均由水均未溶化，也没有通过DMSO（1）+水（2）混合物。温度对所研究的溶液的优先溶剂化幅度有点影响。通过与L-酪氨酸的Lewis基本组相互作用的溶剂相互作用的更高酸性行为，可以解释水的较高溶解。此外，药物的溶解度是通过使用jouyban-antee模型来数学代表，Vane'thoff-jouyban-antee模型和apelblat-jouyban-antee模型获得平均相对偏差对于相关性研究。值得注意的是，本作作品中提出的溶解性数据有助于扩展关于药物在二元溶剂混合物中的溶解性的理化信息，并且还允许各种溶解和特定的热力学分析

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