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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Terphenyl derivatives and terpenoids from a wheat-born mold Aspergillus candidus
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Terphenyl derivatives and terpenoids from a wheat-born mold Aspergillus candidus

机译：来自小麦出生的模具曲霉念珠菌的特苯基衍生物和三萜类化合物

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摘要

A new p-terphenyl derivative aspergicandidusin A (1), a new cleistanthane diterpenoid 6-deoxyaspergiloid C (13), and 12 known compounds (2-12, and 14) were isolated from the mold Aspergillus candidus. The structures of the new compounds were elucidated by spectral analysis of NMR and MS data. The absolute configuration of C-1 in 13 was determined via the circular dichroism data of the [Rh-2(OCOCF3)(4)] complex. Compounds 2-8 and 11 showed moderate inhibitory activity against K562 cell lines with the IC50 value in the range from 17.9 to 46.3 mu M. Compound 13 exhibited moderate cytotoxicity against HepG2 cells with the IC50 value of 47.7 mu M. Compounds 11 and 12 exhibited moderate activity against the growth of S. aureus with MIC value of 6.25 mu M, respectively.
机译：从模具Aspergillus Candidus中分离出一种新的新胚菌曲率A（1）。 通过NMR和MS数据的光谱分析阐明了新化合物的结构。 通过[rh-2（ococf3）（4）]复合物的圆形二色性数据确定C-1中的C-1中的绝对构型。 化合物2-8和11显示了与K562细胞系的中等抑制活性，其IC50值范围为17.9至46.3μm。化合物13与HepG2细胞的中等细胞毒性，IC50值为47.7μm。化合物11和12表现出 适度的活动分别对麦克风的生长分别具有6.25 mu m的MIC值。

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    Han JunJie; Lu FangMing; Bao Li; Wang HanYing; Chen BaoSong; Li ErWei; Wang ZhengDi; Xie LiPing; Guo ChangBin; Xue YanFen; Ma YanHe; Liu HongWei;

  • 作者单位

    Chinese Acad Sci Inst Microbiol State Key Lab Mycol Beijing 100101 Peoples R China;

    Hebei Univ Coll Life Sci Baoding 071002 Peoples R China;

    Chinese Acad Sci Inst Microbiol State Key Lab Mycol Beijing 100101 Peoples R China;

    Hebei Univ Coll Life Sci Baoding 071002 Peoples R China;

    Chinese Acad Sci Inst Microbiol State Key Lab Mycol Beijing 100101 Peoples R China;

    Chinese Acad Sci Inst Microbiol State Key Lab Mycol Beijing 100101 Peoples R China;

    Capital Normal Univ Dept Chem Beijing 100048 Peoples R China;

    Capital Normal Univ Dept Chem Beijing 100048 Peoples R China;

    Capital Normal Univ Dept Chem Beijing 100048 Peoples R China;

    Chinese Acad Sci Inst Microbiol State Key Lab Microbial Resources Beijing 100101 Peoples R China;

    Chinese Acad Sci Inst Microbiol State Key Lab Microbial Resources Beijing 100101 Peoples R China;

    Chinese Acad Sci Inst Microbiol State Key Lab Mycol Beijing 100101 Peoples R China;

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  • 正文语种 eng
  • 中图分类 药学;
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