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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Laxaphycins B5 and B6 from the cultured cyanobacterium UIC 10484
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Laxaphycins B5 and B6 from the cultured cyanobacterium UIC 10484

机译：来自培养的蓝杆菌UIC 10484的Laxaphycins B5和B6

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摘要

Two laxaphycin type-B cyclic dodecapeptides, laxaphycins B5 and B6, were obtained from UIC 10484, a freshwater cf. Phormidium sp. Analysis using the 16S rRNA sequence found UIC 10484 to clade with UIC 10045, a known laxaphycin type-A and -B producer, and MS/MS analysis revealed the presence of two novel laxaphycin type-B compounds. The structures of the metabolites were elucidated using 2D NMR and MS/MS. The absolute configurations of the amino acids were determined by advanced Marfey's analysis. Both metabolites were evaluated against the same three cancer cell lines. The IC50 of both laxaphycins B5 and B6 was near 1 mu M against breast cancer MDA-MB-231, melanoma MDA-MB-435, and ovarian cancer OVCAR3 cell lines.
机译：两种盐蛋白型-B循环十二肽，泻霉素B5和B6，从UIC 10484获得淡水CF。 Phormidium sp。 使用16S rRNA序列发现UIC 10484的分析与UIC 10045的疏水素10045，已知的蒲根霉素型-A和-B生产者，以及MS / MS分析显示出两种新的蒲根霉素型-B化合物的存在。 使用2D NMR和MS / MS阐明代谢物的结构。 氨基酸的绝对构型由高级Marfey的分析确定。 两种代谢物都针对相同的三种癌细胞系评价。 蒲团B5和B6的IC 50对乳腺癌MDA-MB-231，黑素瘤MDA-435和卵巢癌OVCAR3细胞系近1μm。

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