New azaphilones from Penicillium variabile, a fungal endophyte from roots of Aconitum vilmorinianum

Shao Yating; Yan Hui; Yin Tianpeng; Sun Zhongwen; Xie Huiding; Song Liudong; Sun Kongchun; Li Wei

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New azaphilones from Penicillium variabile, a fungal endophyte from roots of Aconitum vilmorinianum

机译：来自青霉霉素的新的共苯胺，来自乌龙炎的根源的真菌内心细胞

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Two new azaphilone derivatives, comazaphilones G and H (1 and 2), together with eight known analogues (3-10), were isolated from an endophytic fungus Penicillium variabile. Their structures were established on the basis of extensive spectroscopic analysis. Compounds 1, 2 and 4-10 were tested their nitric oxide inhibitory activities in lipopolysaccharide-activated RAW 264.7 macrophage cells. Compounds 1, 2 and 4-9 showed significant nitric oxide inhibitory activities with IC50 values ranged from 4.35 +/- 0.05 to 40.52 +/- 0.47 mu M.

机译：两种新的共止向硅衍生物，分离与八个已知的类似物（3-10），与内生真菌青霉蛋白质分离出来。它们的结构是在广泛的光谱分析的基础上建立的。在脂多糖活化的原料264.7巨噬细胞中测试了化合物1,2和4-10的一氧化氮抑制活性。化合物1,2和4-9显示出具有IC50值的显着的一氧化氮抑制活性，范围为4.35 +/- 0.05至40.52 +/- 0.47 mu m。

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来源
《The Journal of Antibiotics: An International Journal》 |2020年第2期|共5页
作者
Shao Yating; Yan Hui; Yin Tianpeng; Sun Zhongwen; Xie Huiding; Song Liudong; Sun Kongchun; Li Wei;
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作者单位

Kunming Med Univ Sch Pharmaceut Sci Kunming Yunnan Peoples R China;

Yunnan Acad Agr Sci Inst Agr Environm &

Resources Beijing Rd 2238 Kunming Yunnan Peoples R;

Zunyi Med Univ Zhuhai Key Lab Fundamental &

Appl Res Tradit Chin Zhuhai Campus Zhuhai Peoples R;

Kunming Med Univ Sch Pharmaceut Sci Kunming Yunnan Peoples R China;

Kunming Med Univ Sch Pharmaceut Sci Kunming Yunnan Peoples R China;

Kunming Med Univ Sch Pharmaceut Sci Kunming Yunnan Peoples R China;

Kunming Med Univ Sch Pharmaceut Sci Kunming Yunnan Peoples R China;

Kunming Med Univ Sch Pharmaceut Sci Kunming Yunnan Peoples R China;

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正文语种 eng
中图分类药学;
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1. New azaphilones from Penicillium variabile, a fungal endophyte from roots of Aconitum vilmorinianum [J] . Shao Yating, Yan Hui, Yin Tianpeng, The Journal of Antibiotics: An International Journal . 2020,第2期

机译：来自青霉霉素的新的共苯胺，来自乌龙炎的根源的真菌内心细胞
2. Evidence for host-specificity of culturable fungal root endophytes fromTI Evidence for host-specificity of culturable fungal root endophytes from the carnivorous plant Pinguicula vulgaris (Common Butterwort) [J] . Quilliam RS, Jones DL Mycological progress . 2012,第2期

机译：来自TI的可培养真菌根内生菌宿主特异性的证据来自食肉植物平菇（Bonguicula vulgaris）的可培养真菌根内生菌宿主特异性的证据
3. The fungal leaf endophyte Paraconiothyrium variabile specifically metabolizes the host-plant metabolome for its own benefit [J] . Tian Yuan, Arnand Severine, Buisson Didier, Phytochemistry . 2014,第Null期

机译：真菌叶片内生菌可变副甲状腺寄生虫可专门代谢宿主植物代谢组
4. Diversity and plant-growth promoting ability of fungal endophytes isolated from oats and eucalyptus roots [C] . S. Teshima, K. Sakamoto International Plant Nutrition Colloquium; 2005; Beijing . 2005

机译：从燕麦和桉树根中分离出来的真菌内生菌的多样性和促进植物生长的能力
5. Dark septate and arbuscular mycorrhizal fungal endophytes in roots of prairie grasses. [D] . Perez-Naranjo, Juan Carlos. 2010

机译：草原草根中有深色的隔片和丛枝菌根真菌内生菌。
6. Genome mining of a fungal endophyte of Taxus yunnanensis (Chinese yew) leads to the discovery of a novel azaphilone polyketide lijiquinone [O] . Jesse W. Cain, Kristin I. Miller, John A. Kalaitzis, 2020

机译：基因组采矿的云南香毒植物的真菌内皮细胞（中国yew）导致了一种新型助产酮聚酮Lijiqueone的发现
7. Two phytotoxic azaphilone derivatives fromChaetomium globosum, a fungal endophyte isolated fromAmaranthus viridisleaves [O] . K.G. Nelum P. Piyasena, W.A.R.T. Wickramarachchi, N. Savitri Kumar, 2015

机译：两种植物毒性的共止向血管衍生物从洛杉矶滴下的真菌内心毒液中分离出来

New azaphilones from Penicillium variabile, a fungal endophyte from roots of Aconitum vilmorinianum

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