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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Geninthiocins C and D from Streptomyces as 35-membered macrocyclic thiopeptides with modified tail moiety
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Geninthiocins C and D from Streptomyces as 35-membered macrocyclic thiopeptides with modified tail moiety

机译：来自链霉素C和D从链霉菌C和D具有改性尾部的35元大环硫肽

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摘要

Geninthiocin is a thiopeptide with 35-membered macrocyclic core moiety. It has potent anti-Gram-positive (G(+)) bacteria activity. Herein, we reported two new congeners (2-3) of geninthiocin (geninthiocin A, 1) from Streptomyces sp. CPCC 200267, and designated them as geninthiocins C and D, whose structures were determined by NMR. Geninthiocins A, C and D had the same 35-membered macrocyclic core moiety, but possessed a -Dha-Dha-NH2, -Dha-Ala-NH2, and -NH2 tail, respectively. Besides, the Ala residue in geninthiocin C was determined as L- configuration by C-3 Marfey's method. In vitro assays indicated that geninthiocins C-D showed no antibacterial activity, in contrast to the potent anti-G(+) bacteria activity displayed by geninthiocin A. Therefore, the -Dha-Dha-NH2 tail of geninthiocin A played an important role in its potent activity against G(+) bacteria.
机译：Geninthiocin是一种硫肽，具有35元大环核心部分。 它具有有效的抗革兰阳性（G（+））细菌活性。 在此，我们报道了来自Streptomyces SP的三辛胺（Geninthiocin A，1）的两种新的Congeners（2-3）。 CPCC 200267，并将其指定为Geninthiocins C和D，其结构由NMR测定。 GenInthiocins A，C和D具有相同的35元大环核心部分，但分别具有-DHA-DHA-NH2，-DHA-ALA-NH2和-NH2尾部。 此外，通过C-3 Marfey的方法确定了基因酮C中的ALA残基作为L-构型。 体外测定表明，GenInthiocins Cd显示出与Geninthiocin A显示的有效抗G（+）细菌活性相比，GenInthiocin A的-DHA-DHA-NH2尾部在其有效方面发挥了重要作用 针对G（+）细菌的活性。

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    Li Shufen; Hu Xinxin; Li Linli; Liu Hongyu; Yu Liyan; You Xuefu; Jiang Bingya; Wu Linzhuan;

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    Chinese Acad Med Sci Inst Med Biotechnol NHC Key Lab Biotechnol Antibiot Beijing 100050 Peoples;

    Chinese Acad Med Sci Inst Med Biotechnol NHC Key Lab Biotechnol Antibiot Beijing 100050 Peoples;

    Chinese Acad Med Sci Inst Med Biotechnol NHC Key Lab Biotechnol Antibiot Beijing 100050 Peoples;

    Chinese Acad Med Sci Inst Med Biotechnol NHC Key Lab Biotechnol Antibiot Beijing 100050 Peoples;

    Chinese Acad Med Sci Inst Med Biotechnol NHC Key Lab Biotechnol Antibiot Beijing 100050 Peoples;

    Chinese Acad Med Sci Inst Med Biotechnol NHC Key Lab Biotechnol Antibiot Beijing 100050 Peoples;

    Chinese Acad Med Sci Inst Med Biotechnol NHC Key Lab Biotechnol Antibiot Beijing 100050 Peoples;

    Chinese Acad Med Sci Inst Med Biotechnol NHC Key Lab Biotechnol Antibiot Beijing 100050 Peoples;

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  • 正文语种 eng
  • 中图分类 药学;
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