...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Antibiotics: An International Journal >Synthesis and antibacterial activity of novel lincomycin derivatives. III. Optimization of a phenyl thiadiazole moiety
【24h】

Synthesis and antibacterial activity of novel lincomycin derivatives. III. Optimization of a phenyl thiadiazole moiety

机译：新型林核糖蛋白衍生物的合成及抗菌活性。 III。 优化苯基噻二唑部分

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Lincomycin derivatives that have a 5-(2-nitrophenyl)-1,3,4-thiadiazol-2-yl thio moiety at the 7-position were synthesized. 5-Substituted 2-nitrophenyl derivatives showed potent antibacterial activities against Streptococcus pneumoniae and Streptococcus pyogenes with erm gene. Antibacterial activities of the 4,5-di-substituted 2-nitrophenyl derivatives were generally comparable to those of telithromycin (TEL) against S. pneumoniae with erm gene and clearly superior to those of TEL against S. pyogenes with erm gene. Compounds 6 and 10c that have a methoxy group at the 5-position of the benzene ring exhibited activities comparable to TEL against Haemophilus influenzae. These results suggest that lincomycin derivatives modified at the 7-position would be promising compounds as a clinical candidate. We would like to dedicate this article to the special issue for late Professor Dr. Hamao Umezawa in The Journal of Antibiotics.
机译：合成含有5-（2-硝基苯基）-1,3,4-噻唑-2-基噻唑-2-基硫代噻唑-2-基硫代噻唑硫醚的延伸蛋白衍生物被合成了7-位。 5-取代的2-硝基苯基衍生物显示出与ERM基因的肺炎链球菌和链球菌化脓性的有效的抗菌活性。 4,5-二取代的2-硝基苯基衍生物的抗菌活性通常与具有ERM基因的汽油霉素（Tel）对抗S.肺炎的那些，并且明显优于与ERM基因的Tel对抗S. pyogenes的那些。 在苯环5位的化合物6和10C，在苯环的5-位表现出与Tel对抗嗜血杆菌嗜血杆菌的活性。 这些结果表明，在7位修饰的林霉素衍生物将是有前途的化合物作为临床候选者。 我们想将这篇文章致力于抗生素杂志Hameo Umezawa博士的特殊问题。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号