Enantiospecific total synthesis of the squalene synthase inhibitors (-)-CJ-13,982 and its enantiomer from a common intermediate

Sturgess Dayna; Chen Zongjia; White Jonathan M.; Rizzacasa Mark A.

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Enantiospecific total synthesis of the squalene synthase inhibitors (-)-CJ-13,982 and its enantiomer from a common intermediate

机译：中苯二烯合酶抑制剂（ - ） - CJ-13,982与常见中间体的对映异常合成

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摘要

The total syntheses of both the natural and unnatural enantiomers of the alkyl citrate natural product CJ-13,982 (1) from the common D-ribose-derived acid 6 are described.

机译：描述了来自共同的D-核糖衍生的酸6的烷基柠檬酸烷基天然产物CJ-13,982（1）的天然和非天然对映体的总合成。

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《The Journal of Antibiotics: An International Journal》 |2018年第2期|共6页
作者
Sturgess Dayna; Chen Zongjia; White Jonathan M.; Rizzacasa Mark A.;
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Univ Melbourne Inst Bio21 Sch Chem 30 Flemington Rd Parkville Vic 3010 Australia;

Univ Melbourne Inst Bio21 Sch Chem 30 Flemington Rd Parkville Vic 3010 Australia;

Univ Melbourne Inst Bio21 Sch Chem 30 Flemington Rd Parkville Vic 3010 Australia;

Univ Melbourne Inst Bio21 Sch Chem 30 Flemington Rd Parkville Vic 3010 Australia;

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正文语种 eng
中图分类药学;
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1. Enantiospecific total synthesis of the squalene synthase inhibitors (-)-CJ-13,982 and its enantiomer from a common intermediate [J] . Sturgess Dayna, Chen Zongjia, White Jonathan M., The Journal of Antibiotics: An International Journal . 2018,第2期

机译：中苯二烯合酶抑制剂（ - ） - CJ-13,982与常见中间体的对映异常合成
2. Enantiospecific total synthesis of the enantiomer of the indole alkaloid intermediate macroline [J] . Xiaoxiang Liu, Chunchun Zhang, Xuebin Liao, Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2002,第41期

机译：吲哚生物碱中间体大分子对映体的对映体全合成
3. Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C [J] . Seiichi Nakamura Chemical and Pharmaceutical Bulletin . 2005,第1期

机译：角鲨烯合酶抑制剂Zaragozic Acid C的全合成
4. Farnesyltransferase Inhibitors: From Squalene Synthase Inhibitors to the Clinical Agent BMS-214662 [C] . John T. Hunt American Chemical Society . 2001

机译：法呢基转移酶抑制剂：从Squalene合酶抑制剂到临床药物BMS-214662
5. Part One. Synthesis of optically active tryptophan derivatives with potential activity as indoleamine 2,3-dioxygenase inhibitors: An approach via asymmetric catalytic hydrogenation. Part Two. Design, synthesis and pharmacology of selective ligands for alpha1-containing GABA(A)/benzodiazepine receptor subtypes: SAR studies of beta-carbolines at positions -3 and -6 and their corresponding bivalent ligands. Part Three. First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A. [D] . Yin, Wenyuan. 2007

机译：第一部分。具有吲哚胺2,3-二加氧酶抑制剂潜在活性的旋光色氨酸衍生物的合成：一种通过不对称催化氢化的方法。第二部分。含α1的GABA（A）/苯并二氮杂receptor受体亚型的选择性配体的设计，合成和药理作用：位于-3和-6位的β-咔啉及其相应的二价配体的SAR研究。第三部分。重要生物遗传中间体，（+）-聚神经氨酸和（+）-聚神经氨酸醛，以及16-表-维西辛和Macusine A的首次对映体全合成。
6. Enantiospecific Total Synthesis of the Important Biogenetic Intermediates Along the Ajmaline Pathway (+)-Polyneuridine and (+)-Polyneuridine Aldehyde as well as 16-Epi-Vellosimine and Macusine A [O] . Wenyuan Yin, M. Shahjahan Kabir, Zhijian Wang, -1

机译：重要生物遗传中间体沿阿马林途径的对映体全合成（+） - polyneuridine和（+） - polyneuridine醛以及16-EpI-Vellosimine和macusine一
7. Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C [O] . Seiichi Nakamura 2005

机译：Squalene合成酶抑制剂Zaragozic酸C的总合成

Enantiospecific total synthesis of the squalene synthase inhibitors (-)-CJ-13,982 and its enantiomer from a common intermediate

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