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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Dipyrimicin A and B, microbial compounds isolated from Amycolatopsis sp K16-0194
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Dipyrimicin A and B, microbial compounds isolated from Amycolatopsis sp K16-0194

机译：偶氮霉素A和B，微生物化合物从Amycolatopsis SP K16-0194中分离

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摘要

In a search for compounds interacting with ergosterol resin, a new compound named dipyrimicin B was isolated from a rare actinomycete strain, Amycolatopsis sp. K16-0194. In addition, another analog, dipyrimicin A, which does not interact with the resin, was also discovered. The structures of the two dipyrimicins were established by comprehensive 1D and 2D NMR and MS analyses and found to contain a unique core structure, a 2,2'-bipyridine skeleton. Dipyrimicin A showed strong antimicrobial and cytotoxic activity, whereas dipyrimicin B displayed distinctly poor antimicrobial and cytotoxic activities.
机译：在寻找与Ergoster醇树脂相互作用的化合物中，从稀有的放射瘤菌株，amycolatopsis sp中分离出一种称为偶氮霉素B的新化合物。 K16-0194。 另外，还发现了不与树脂相互作用的另一种类似的偶二霉素A. 通过全面的1D和2D NMR和MS分析建立了两种偶氮蛋白的结构，发现含有独特的核心结构，2,2'-双吡啶骨架。 司霉素A显示出强烈的抗菌和细胞毒性活性，而北霉素B展示明显差的抗菌和细胞毒性活性。

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    Izuta Shoko; Kosaka Shohei; Kawai Makoto; Miyano Rei; Matsuo Hirotaka; Matsumoto Atsuko; Nonaka Kenichi; Takahashi Yoko; Omura Satoshi; Nakashima Takuji;

  • 作者单位

    Kitasato Univ Grad Sch Infect Control Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Fuji Silysia Chem Ltd Team Mirai Grp 2-1846 Kozoji Cho Kasugai Aichi 4870013 Japan;

    Fuji Silysia Chem Ltd Team Mirai Grp 2-1846 Kozoji Cho Kasugai Aichi 4870013 Japan;

    Kitasato Univ Grad Sch Infect Control Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Grad Sch Infect Control Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Grad Sch Infect Control Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Grad Sch Infect Control Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Kitasato Inst Life Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Kitasato Inst Life Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Grad Sch Infect Control Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

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  • 正文语种 eng
  • 中图分类 药学;
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