4'''-N-demethylspiramycin derivatives: synthesis and evaluation of effectiveness against drug-resistant bacteria.

Sunazuka T; Shudo H; Nagai K; Yoshida K; Yamaguchi Y; Hanaki H; Omura S

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4'''-N-demethylspiramycin derivatives: synthesis and evaluation of effectiveness against drug-resistant bacteria.

机译：4''' - N-脱甲基氨基霉素衍生物：对耐药细菌有效性的合成和评价。

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18-amino-4''-O-benzoyl-4'''-N-demethyl-18-deoxospiramycins were designed and synthesized. Synthetic strategy involved selective demethylation of the dimethylamino group in forosamine, benzoylation of the hydroxyl group at the C4'' position and reductive N-amination of the formyl group. Antibacterial characteristics of spiramycin derivatives were tested. The derivatives exhibited promising activity against drug-resistant bacterial strains.

机译：设计和合成了18-氨基-4' - O-Benzoyl-4''' - N-甲基-18-脱氧血清霉素。合成策略涉及甲氨磺酰胺中二甲基氨基的选择性去甲基化，羟基在C4''位置和甲酰基的还原N-胺化上的苯甲酰胺。测试螺霉素衍生物的抗菌特性。衍生物表现出对抗耐药细菌菌株的有希望的活性。

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来源
《The Journal of Antibiotics: An International Journal》 |2008年第3期|共10页
作者
Sunazuka T; Shudo H; Nagai K; Yoshida K; Yamaguchi Y; Hanaki H; Omura S;
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作者单位

Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences Kitasato;

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正文语种 eng
中图分类药学;
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1. 4'''-N-demethylspiramycin derivatives: synthesis and evaluation of effectiveness against drug-resistant bacteria. [J] . Sunazuka T, Shudo H, Nagai K, The Journal of Antibiotics: An International Journal . 2008,第3期

机译：4'''-N-去甲基螺旋霉素衍生物：合成和评估抗药性细菌的功效。
2. 4'''-N-demethylspiramycin derivatives: synthesis and evaluation of effectiveness against drug-resistant bacteria. [J] . Sunazuka T, Shudo H, Nagai K, The Journal of Antibiotics: An International Journal . 2008,第3期

机译：4''' - N-脱甲基氨基霉素衍生物：对耐药细菌有效性的合成和评价。
3. 4'''-N-demethylspiramycin derivatives: synthesis and evaluation of effectiveness against drug-resistant bacteria. [J] . Sunazuka T, Shudo H, Nagai K, The Journal of Antibiotics: An International Journal . 2008,第3期

机译：4''' - N-脱甲基氨基霉素衍生物：对耐药细菌有效性的合成和评价。
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4'''-N-demethylspiramycin derivatives: synthesis and evaluation of effectiveness against drug-resistant bacteria.

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