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首页> 外文期刊>The Journal of craniofacial surgery >High-Grade Conventional Osteosarcoma of the Mandible Associated With P53 Germline Mutation
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High-Grade Conventional Osteosarcoma of the Mandible Associated With P53 Germline Mutation

机译：高级常规骨肉瘤的下颌骨与p53种系突变相关

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摘要

High-grade conventional osteosarcoma of the mandible is a rare entity that can manifest as a rapidly growing mass. The authors report the case of a young adult patient with right mandible pain and swelling and a history of humeral osteosarcoma treated over 1 decade earlier. Computed tomography and magnetic resonance imaging showed a mass arising from the right mandible that progressed despite induction chemotherapy and the patient underwent surgery. Histopathology revealed the presence of malignant osteoblasts and osteoid, which led to the diagnosis of high-grade conventional osteosarcoma. There were also regional lymph node metastases. Genetic testing revealed a p53 germline mutation. The presence of mandibular osteosarcoma in a young patient should raise the suspicion of an underlying p53 germline mutation. Ultimately, the recurrent tumor regressed with Etoposide and Ifosfamide.
机译：下颌骨的高级常规骨肉瘤是一种罕见的实体，可以表现为迅速增长的质量。 作者举报了一个右下颌骨疼痛和肿胀的年轻成人患者的案例，肱骨骨肉瘤的历史早些时候在1年内待遇。 计算断层扫描和磁共振成像显示出尽管诱导化疗和患者接受手术的右颌骨，所以巨大的下颌骨产生的质量。 组织病理学揭示了恶性成骨细胞和骨质的存在，导致了高档常规骨肉瘤的诊断。 还有区域淋巴结转移。 基因检测显示P53种系突变。 年轻患者中颌骨骨肉瘤的存在应提高潜在的P53种系突变。 最终，复发性肿瘤用依托泊苷和Ifosfamide回归。

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