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首页> 外文期刊>The Journal of Nutritional Biochemistry >Effect of annatto-extracted tocotrienols and green tea polyphenols on glucose homeostasis and skeletal muscle metabolism in obese male mice
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Effect of annatto-extracted tocotrienols and green tea polyphenols on glucose homeostasis and skeletal muscle metabolism in obese male mice

机译：Annatto提取的Tocotrienols和绿茶多酚对肥胖稳态和骨骼肌代谢的影响

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Skeletal muscle is the major site for glucose uptake and thus plays an important role in initiating insulin resistance in type 2 diabetes mellitus. This study evaluated the effects of tocotrienols (TT) and green tea polyphenols (GTP) individually or in combination on glucose homeostasis and skeletal muscle metabolism in obese mice with insulin resistance and elevation of blood glucose. Forty-eight male mice were fed a high-fat diet and assigned to 4 groups in a 2 (no TT vs. 400 mg TT/kg diet) x 2 (no GTP vs. 0.5% vol/wt GTP in water) for 14 weeks. Both GTP and TT improved area under curve of insulin intolerance; while GTP increased serum insulin levels in obese mice, probably due to the addition of sweetener in drinking water. An interaction (TTxGTP) was observed in glucose tolerance test, total pancreas insulin concentration, and citrate synthase activity of soleus in mice. Neither IT nor GTP affected insulin and glucagon protein expression in pancreas based on immunohistochemistry. Both TT and GTP individually increased soleus muscle weight of mice; while only GTP increased gastrocnemius muscle weight of mice. The TT+GTP group had the greatest gastrocnemius muscle cross sectional area than other groups. GTP, not TT, induced cytochrome c oxidase activity and reduced thiobarbituric acid reactive substances levels in soleus muscle. Our results suggest that TT and GTP, individually or synergistically have the potential to improve skeletal muscle metabolism in obese mice by improving glucose homeostasis, reducing lipid peroxidation, and increasing rate limiting enzymes of oxidative phosphorylation. (C) 2019 Published by Elsevier Inc.
机译：骨骼肌是葡萄糖摄取的主要部位，从而在启动2型糖尿病患者的胰岛素抵抗中起重要作用。该研究评估了Tocotrienols（TT）和绿茶多酚（GTP）的作用单独或组合在肥胖小鼠中的葡萄糖稳态和骨骼肌代谢，血糖胰岛素抵抗和血糖升高。将四十八只雄性小鼠喂养高脂饮食并分配到4组（NO TT与400mg TT / kg饮食）x 2（在水中没有GTP与0.5％Vol / Wt GTP）14周。在胰岛素不耐受曲线下GTP和TT改进区域;虽然GTP增加了肥胖小鼠的血清胰岛素水平，但可能是由于在饮用水中添加甜味剂。在葡萄糖耐受试验，总胰腺胰岛素浓度和小鼠中柠檬酸盐合酶活性观察到相互作用（TTXGTP）。基于免疫组织化学，既不会影响胰岛素和胰高血糖素蛋白表达。 TT和GTP都分别增加了小鼠的肌肉重量;虽然只有GTP增加了小鼠的腓肠肌重量。 TT + GTP组具有比其他群体最大的腓肠肌横截面积。 GTP，而不是TT，诱导细胞色素C氧化酶活性，并降低Soleus肌肉中的硫酰腺酸反应物质水平。我们的研究结果表明，通过改善葡萄糖稳态，降低脂质过氧化和增加氧化磷酸化的速率限制酶来单独或协同地具有改善肥胖小鼠骨骼肌代谢的可能性。 （c）2019由elsevier公司出版

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