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首页> 外文期刊>The Journal of Nutritional Biochemistry >Novel metabolic disturbances in marginal vitamin B-6-deficient rat heart
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Novel metabolic disturbances in marginal vitamin B-6-deficient rat heart

机译：新颖的维生素B-6缺乏大鼠心脏的新代谢紊乱

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摘要

Vitamin B-6 deficiency is associated with cardiovascular disease (CVD). Although plasma biomarkers have been proposed, no studies have yet directly profiled heart tissue, and the mechanisms have to be fully defined. Thus, in order to provide better insight into vitamin B-6-deficient effects on cardiac functions, we sought to identify the metabolic profile in heart tissue consequent to change in dietary vitamin B-6 levels by applying metabolomics. Heart tissues of rats fed a basal diet containing a marginal vitamin B-6-deficient, vitamin B-6 -recommended or vitamin B-6-supplemented level were analyzed by metabolomics analysis. Among over 500 detected metabolites, imidazole metabolites including carnosine, anserine, homocarnosine and histamine exhibited the highest decrease upon vitamin B-6 deficiency (>-45%, P.01), along with their precursors beta-alanine, gamma-aminobutyric acid (GABA) and 1-methylhistidine. Ornithine was the only metabolite exhibiting an increased level in the vitamin B-6-deficient group. Vitamin B-6 deficiency significantly attenuated the activity of heart tissue glutamate decarboxylase (GAD), although there was undetectable activity of aspartate decarboxylase (ADC), suggesting that the involvement of vitamin B-6 in imidazole metabolite synthesis occurs partly through GABA production by regulating GAD rather than through a straightforward beta-alanine production pathway via ADC in the heart. Notably, vitamin B-6 deficiency significantly attenuated citric acid cycle metabolite levels, suggesting cardiac energy metabolism impairment. This study provides a new link between vitamin B-6 and cardiac functions, in which marginal vitamin B-6 deficiency impairs imidazole and energy metabolism in heart. This newly revealed cardiac metabolic profile may reveal novel molecular targets or foodstuffs for CVD prevention. (C) 2018 Elsevier Inc. All rights reserved.
机译：维生素B-6缺乏症与心血管疾病（CVD）有关。虽然已经提出了血浆生物标志物，但没有研究尚未直接成型心脏组织，并且必须完全定义机制。因此，为了提供更好地探视维生素B-6对心脏功能的影响，我们试图通过施加代谢组学改变膳食维生素B-6水平的心脏组织中的代谢型材。通过代谢组分析分析了含有边缘维生素B-6缺陷的基础饮食的大鼠饲喂含有边缘维生素B-6缺陷的基础饮食，维生素B-6 - 6-6补充水平。在500多种检测到的代谢物中，咪唑代谢物，包括肉核苷酸，碘，同种肉瘤和组胺，在维生素B-6缺乏（> -45％，P＆ 01）上表现出最高的降低（> -45％，p <.01），以及它们的前体β-丙氨酸，γ-氨基丁酸（GABA）和1-甲基氨基氨基。鸟氨酸是在维生素B-6缺陷组中表现出较高水平的唯一代谢物。维生素B-6缺乏显着减弱了心脏组织谷氨酸脱羧酶（GAD）的活性，尽管天冬氨酸脱羧酶（ADC）的不可检测的活性，表明维生素B-6在咪唑代谢物合成中的参与部分通过COMENATION部分通过GABA生产发生GAD而不是通过心脏ADC通过简单的β-丙氨酸生产途径。值得注意的是，维生素B-6缺乏显着减弱柠檬酸循环代谢物水平，表明心能代谢障碍。本研究提供了维生素B-6和心脏功能之间的新联系，其中边际维生素B-6缺乏症在心脏中损害咪唑和能量代谢。这种新揭示的心脏代谢型材可以揭示用于CVD预防的新型分子靶标或食品。 （c）2018年Elsevier Inc.保留所有权利。

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