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首页> 外文期刊>The Journal of Nutritional Biochemistry >Dietary patterns influence epicardial adipose tissue fatty acid composition and inflammatory gene expression in the Ossabaw pig
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Dietary patterns influence epicardial adipose tissue fatty acid composition and inflammatory gene expression in the Ossabaw pig

机译：膳食模式影响心外膜脂肪组织脂肪酸组成和骨肉猪中的炎症基因表达

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摘要

Epicardial adipose tissue (EAT) inflammation is implicated in the development and progression of coronary atherosclerosis. Dietary saturated and polyunsaturated fatty acids (SFAs and PUFA) can influence adipose tissue inflammation. We investigated the influence of dietary patterns, with emphasis on dietary fat type, and statin therapy, on EAT fatty acid (FA) composition and inflammatory gene expression. Thirty-two Ossabaw pigs were fed isocaloric amounts of a Heart Healthy (high in unsaturated fat) or Western (high in saturated fat) diets +/- atorvastatin for 6 months. EAT FA composition reflected dietary fat composition. There was no significant effect of atorvastatin on EAT FA composition. Total and long-chain SFAs were positively associated with inflammatory signaling (TLR2) and a gene involved in lipid mediator biosynthesis (PTGS2) (P<.0003). Medium-chain SFAS capric and lauric acids were negatively associated with 1L-6 (all P<.0003). N-6 and n-3 PUFAs were positively associated with anti-inflammatory signaling genes (PPARG, FFAR4 and AD1POQ) and long-chain n-3 PUFAs were positively associated with a gene involved in lipid mediator biosynthesis (ALOX5) (all P<.0003). These data indicate that dietary patterns, differing in fat type, influence EAT FA composition. Associations between EAT SFAS, PUFAs, and expression of genes related to inflammation provide a link between dietary quality and EAT inflammation. (C) 2019 Elsevier Inc. All rights reserved.
机译：心外膜脂肪组织（吃）炎症涉及冠状动脉粥样硬化的发展和进展。饮食饱和和多不饱和脂肪酸（SFAS和PUFA）可以影响脂肪组织炎症。我们调查了饮食模式的影响，重点是饮食脂肪型，以及吃脂肪酸（FA）组成和炎症基因表达的饮食脂肪型。将三十二骨猪喂食心脏健康（高饱和脂肪）或西方（高饱和脂肪）饮食+/-阿托伐他汀6个月的异常量。吃足总成分反射膳食脂肪组成。阿托伐他汀对吃的成种组成没有显着影响。总和长链SFA与炎症信号传导（TLR2）和脂质介质生物合成（PTGS2）的基因呈正相关（P <.0003）。中链SFAS Capric和月桂酸与1L-6负相关（所有P <.0003）。 N-6和N-3 PUFA与抗炎信号态基因（PPARG，FFAR4和AD1POQ）呈正相关（PPARG，FFAR4和AD1POQ）和长链N-3 PUFA与脂质介质生物合成的基因正相关（Alox5）（所有P < .0003）。这些数据表明饮食模式，脂肪型不同，影响饮食FA组成。吃SFAS，PUFA和与炎症相关基因的表达之间的关联提供膳食质量和炎症之间的联系。 （c）2019 Elsevier Inc.保留所有权利。

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    Walker Maura E.; Matthan Nirupa R.; Goldbaum Audrey; Meng Huicui; Lamon-Fava Stefania; Lakshman Sukla; Jang Saebyeol; Molokin Aleksey; Solano-Aguilar Gloria; Urban Joseph F. Jr.; Lichtenstein Alice H.;

  • 作者单位

    Tufts Univ Jean Mayer USDA Human Nutr Res Ctr Aging Cardiovasc Nutr Lab 711 Washington St Boston MA 02111 USA;

    Tufts Univ Jean Mayer USDA Human Nutr Res Ctr Aging Cardiovasc Nutr Lab 711 Washington St Boston MA 02111 USA;

    Tufts Univ Jean Mayer USDA Human Nutr Res Ctr Aging Cardiovasc Nutr Lab 711 Washington St Boston MA 02111 USA;

    Tufts Univ Jean Mayer USDA Human Nutr Res Ctr Aging Cardiovasc Nutr Lab 711 Washington St Boston MA 02111 USA;

    Tufts Univ Jean Mayer USDA Human Nutr Res Ctr Aging Cardiovasc Nutr Lab 711 Washington St Boston MA 02111 USA;

    ARS USDA Beltsville Human Nutr Res Ctr Diet Genom &

    Immunol Lab 10300 Baltimore Ave Beltsville MD 20705 USA;

    ARS USDA Beltsville Human Nutr Res Ctr Diet Genom &

    Immunol Lab 10300 Baltimore Ave Beltsville MD 20705 USA;

    ARS USDA Beltsville Human Nutr Res Ctr Diet Genom &

    Immunol Lab 10300 Baltimore Ave Beltsville MD 20705 USA;

    ARS USDA Beltsville Human Nutr Res Ctr Diet Genom &

    Immunol Lab 10300 Baltimore Ave Beltsville MD 20705 USA;

    ARS USDA Beltsville Human Nutr Res Ctr Diet Genom &

    Immunol Lab 10300 Baltimore Ave Beltsville MD 20705 USA;

    Tufts Univ Jean Mayer USDA Human Nutr Res Ctr Aging Cardiovasc Nutr Lab 711 Washington St Boston MA 02111 USA;

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  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    Epicardial adipose tissue; Fatty acids; Dietary patterns; Dietary fat; Ossabaw; Atorvastatin;

    机译：心外膜脂肪组织;脂肪酸;饮食模式;膳食脂肪;奥塞拉伐;阿托伐他汀;

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