• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biotechnology Progress >A biochemical logic gate using an enzyme and its inhibitor. 1. Theinhibitor as switching element
【24h】

A biochemical logic gate using an enzyme and its inhibitor. 1. Theinhibitor as switching element

机译：使用酶及其抑制剂的生化逻辑门。 1.抑制剂作为开关元件

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Molecular-scale logic systems will allow for further miniaturization of information processing assemblies and contribute to a better understanding of brain function. Of much interest are the pertinent biological systems, some of the basic components of which are biomolecular switching elements and enzyme-based logic gates. In this series of accounts, results of investigations are presented on the implementation of an enzyme/inhibitor logic gate operating under the rules of Boolean algebra. In this report (part 1 of the series), consideration is given to the experimental conditions-particularly the irradiation mode-that affect the performance of proflavine as inhibitor of alpha-chymotrypsin. Also, assessments are made on the reversibility of the process involved and the long-term stability of the system. Moreover, using a theoretical conformational analysis of proflavine and its reduction products, detailed features were established regarding their three-dimensional structure, partial charge distribution, and hydrophobicity. Accordingly, an understanding was reached as to the factors affecting the interaction between these compounds and the enzyme. In part 2 of this series, the actual implementation of an AND logic gate will be presented. This gate involves proflavine and a chemically derivatized alpha-chymotrypsin, and its operation relies on the conclusions reached in this report regarding the optimal mode far controlling the inhibitory activity of proflavine.
机译：分子级逻辑系统将使信息处理组件进一步小型化，并有助于更好地理解大脑功能。有关的生物系统引起了人们极大的兴趣，其中的一些基本组件是生物分子开关元件和基于酶的逻辑门。在这一系列的报告中，将介绍有关在布尔代数规则下运行的酶/抑制剂逻辑门的研究结果。在本报告中（该系列的第1部分），考虑了影响条件（特别是辐射方式）的实验条件，这些条件会影响前黄素作为α-胰凝乳蛋白酶抑制剂的性能。此外，还会对所涉及过程的可逆性和系统的长期稳定性进行评估。此外，使用对黄酮类化合物及其还原产物的理论构象分析，建立了有关它们的三维结构，部分电荷分布和疏水性的详细特征。因此，对影响这些化合物与酶之间相互作用的因素达成了共识。在本系列的第2部分中，将介绍AND逻辑门的实际实现。此门涉及前黄素和化学衍生的α-胰凝乳蛋白酶，其操作依赖于本报告中关于控制前黄素抑制活性的最佳模式的结论。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号