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首页> 外文期刊>The Journal of toxicological sciences >Hair-to-blood ratio and biological half-life of mercury: experimental study of methylmercury exposure through fish consumption in humans.
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Hair-to-blood ratio and biological half-life of mercury: experimental study of methylmercury exposure through fish consumption in humans.

机译：汞的血液比例和生物半衰期：通过人类鱼类消费的甲基汞暴露的实验研究。

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The hair-to-blood ratio and biological half-life of methylmercury in a one-compartment model seem to differ between past and recent studies. To reevaluate them, 27 healthy volunteers were exposed to methylmercury at the provisional tolerable weekly intake (3.4 μg/kg body weight/week) for adults through fish consumption for 14 weeks, followed by a 15-week washout period after the cessation of exposure. Blood was collected every 1 or 2 weeks, and hair was cut every 4 weeks. Total mercury (T-Hg) concentrations were analyzed in blood and hair. The T-Hg levels of blood and hair changed with time (p < 0.001). The mean concentrations increased from 6.7 ng/g at week 0 to 26.9 ng/g at week 14 in blood, and from 2.3 to 8.8 μg/g in hair. The mean hair-to-blood ratio after the adjustment for the time lag from blood to hair was 344 ± 54 (S.D.) for the entire period. The half-lives of T-Hg were calculated from raw data to be 94 ± 23 days for blood and 102 ± 31 days for hair, but the half-lives recalculated after subtracting the background levels from the raw data were 57 ± 18 and 64 ± 22 days, respectively. In conclusion, the hair-to-blood ratio of methylmercury, based on past studies, appears to be underestimated in light of recent studies. The crude half-life may be preferred rather than the recalculated one because of the practicability and uncertainties of the background level, though the latter half-life may approximate the conventional one.
机译：在一个隔室模型中甲基汞的血液比例和生物半衰期似乎在过去和最近的研究之间有所不同。为了重新评估它们，通过鱼类消费14周，将27个健康的志愿者暴露于临时可耐受的每周摄入（3.4μg/ kg体重/周）的甲基汞，然后在禁止暴露后进行15周的洗涤期。每1或2周收集血液，每4周切割头发。在血液和头发中分析了汞（T-Hg）浓度。 T-Hg水平血液和头发随时间而变化（P <0.001）。平均浓度在血液中的第14周的每周0至26.9 ng / g的每周0至26.9 ng / g中增加，头发中的2.3〜8.8μg/ g。在整个时期，从血液中延迟调节后的平均血液比率为344±54（S.D.）。从原始数据计算T-Hg的半衰期为血液的94±23天和头发102±31天，但从原始数据中减去背景水平后重新计算的半衰期为57±18和64分别为±22天。总之，根据过去的研究，甲基汞的头发血液比率似乎在最近的研究中被低估了。由于背景水平的实用性和不确定性，粗半衰期可能是优选的，而不是重新计算的半衰期，尽管后半衰期可以近似传统的。

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