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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Men Sustain Higher Dysregulation Levels Than Women Without Becoming Frail
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Men Sustain Higher Dysregulation Levels Than Women Without Becoming Frail

机译：男性维持比女性更高的失调水平，而不会变得虚弱

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The aging process differs in important ways between the sexes, with women living longer but at higher risk for frailty (the male–female health-survival paradox). The underlying biological mechanisms remain poorly understood, but may relate to sex differences in physiological dysregulation patterns. Here, using biomarkers from two longitudinal cohort studies (InCHIANTI and BLSA) and one cross-sectional survey (NHANES), we assess sex differences in trajectories of dysregulation globally and for five physiological systems: oxygen transport, electrolytes, hematopoiesis, lipids, and liver/kidney function. We found higher dysregulation levels in men, both globally and in the oxygen transport and hematopoietic systems (p < .001 for all), though differences for other systems were mixed (electrolytes) or absent (lipids and liver/kidney). There was no clear evidence for sex differences in rates of change in dysregulation with age. Although risk of frailty and mortality increase with dysregulation, there was no evidence for differences in these effects between sexes. These findings imply that the greater susceptibility of women to frailty is not simply due to a tolerance for higher dysregulation; rather, it may actually be men that have a greater tolerance for dysregulation, creating a male–female dysregulation-frailty paradox. However, the precise physiological mechanisms underlying the sex differences appear to be diffuse and hard to pin down.
机译：老化过程在性别之间的重要方面不同，女性生活较长，但脆弱的风险更高（男性女性健康悖论）。潜在的生物机制仍然明白，但可能涉及生理失调模式的性别差异。在这里，使用来自两个纵向队列研究的生物标志物（inchianti和blsa）和一个横断面调查（Nhanes），我们评估全球失效轨迹的性别差异，并为五个生理系统：氧气运输，电解质，血小霉，脂质和肝脏/肾功能。我们在全球和氧气输送和造血系统中发现了更高的男性的失调水平（所有血管发作），尽管对其他系统的差异混合（电解质）或不存在（脂质和肝脏/肾脏）。没有明确的证据表明性别差异，随着年龄的增长而变化的变化率。虽然脆弱和死亡率的风险随着多发性增加而增加，但在性别之间没有证据表明这些影响的差异。这些发现意味着妇女更大的易感性不仅仅是由于对更高的失调量的耐受性;相反，它实际上可能是具有更大耐受性耐受性的男性，形成一个男性女性失效 - 脆弱的悖论。然而，性别差异的精确生理机制似乎是弥漫性的，并且难以放下。

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