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Neurocognitive deficits in HIV-infected women and victims of childhood trauma

机译:艾滋病毒感染妇女和儿童创伤受害者的神经认知缺陷

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The study investigated the behavioral and brain effects of childhood trauma and human immunodeficiency virus (HIV) infection, both separately and in combination, and assessed potential interactions in women who were dually affected. Eighty-three HIV-positive and 47 matched HIV-negative South African women underwent neuromedical, neuropsychiatric, and neurocognitive assessments. Univariate tests of significance assessed if either HIV infection or childhood trauma, or the combination, had a significant effect on neurocognitive performance. The majority of women were Black (96%) and had an average age of 30 years. An analysis of covariance revealed significant HIV effects for the Hopkins Verbal Learning Test (HVLT) learning and delay trials (p < 0.01) and the Halstead Category Test (HCT) (p < 0.05). A significant trauma effect was seen on the HVLT delay trial (p < 0.05). The results provide evidence for neurocognitive dysfunction in memory and executive functions in HIV-infected women and memory disturbances in trauma exposed women.
机译:该研究分别调查了儿童创伤和人类免疫缺陷病毒(HIV)感染的行为和大脑影响,并分别进行了研究,并评估了受到双重影响的女性的潜在相互作用。 83名艾滋病毒阳性和47名艾滋病毒阴性的南非妇女接受了神经医学,神经精神病学和神经认知评估。单因素显着性检验评估了艾滋病毒感染或儿童期创伤或两者的结合是否对神经认知能力有重大影响。大部分女性是黑人(96%),平均年龄为30岁。协方差分析显示,对于霍普金斯言语学习测验(HVLT)学习和延迟试验(p <0.01)和Halstead类别测验(HCT)(p <0.05),艾滋病毒具有显着影响。在HVLT延迟试验中看到了显着的创伤效果(p <0.05)。该结果为HIV感染妇女记忆和执行功能的神经认知功能障碍以及受创伤妇女的记忆障碍提供了证据。

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