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首页> 外文期刊>AIDS care. >Home-based study of anti-HIV drug regimen adherence among HIV-infected women: feasibility and preliminary results.
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Home-based study of anti-HIV drug regimen adherence among HIV-infected women: feasibility and preliminary results.

机译:对艾滋病毒感染妇女中抗艾滋病毒药物依从性的家庭研究:可行性和初步结果。

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摘要

Collection of antiretroviral medication adherence data in the homes of HIV-infected people may have methodological advantages that can improve data quality. However, the feasibility of this approach has not been established. In addition, data on adherence, and its predictors, among HIV-infected women have been limited. Sixty-three HIV-positive women who were prescribed at least one antiretroviral drug in the last month were interviewed in their homes. A standard instrument was used to collect data on all antiretroviral medications prescribed and taken in the three days prior to the interview. Data were also collected on factors thought potentially to affect the ability to be adherent. The results of this study suggest that it is feasible to conduct home-based adherence research. Sixty-seven per cent reported taking all prescribed antiretroviral medication doses. One-third took a sub-optimal dose putting themselves at increased risk of treatment failure and the selection of resistant HIV strains. Unintentional reasons for missing doses were most commonly reported. An ability to describe the intended effect of antiretroviral therapy on HIV viral load was the best predictor of adherence. This finding is consistent with other research suggesting that adherence is associated with an understanding and belief in the effectiveness of antiretroviral therapy.
机译:在HIV感染者家中收集抗逆转录病毒药物依从性数据可能具有可以改善数据质量的方法优势。但是,这种方法的可行性尚未确定。此外,受艾滋病毒感染的妇女中依从性及其预测因素的数据也很有限。在上个月接受了63例HIV阳性女性的妇女采访,她们在上个月接受了至少一种抗逆转录病毒药物的处方。在采访前三天,使用标准仪器收集所有处方和服用的所有抗逆转录病毒药物的数据。还收集了有关可能影响依从性的因素的数据。这项研究的结果表明进行家庭依从性研究是可行的。 67%的人报告服用了所有规定的抗逆转录病毒药物剂量。三分之一的人服用次优剂量,使自己面临治疗失败和选择抗药性HIV菌株的风险增加。最常见的报道是缺少剂量的意外原因。描述抗逆转录病毒疗法对HIV病毒载量的预期效果的能力是依从性的最佳预测指标。这一发现与其他研究一致,表明依从性与对抗逆转录病毒疗法有效性的理解和信仰有关。

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