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首页> 外文期刊>AIDS care. >Prediction of adherence to antiretroviral therapy: A one-year longitudinal study.
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Prediction of adherence to antiretroviral therapy: A one-year longitudinal study.

机译：对抗逆转录病毒疗法依从性的预测：一项为期一年的纵向研究。

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The aim of this longitudinal study was to identify the determinants of adherence to antiretroviral therapy (ART) in HIV patients over a period of 12 months. A total of 376 individuals living with HIV treated with ART participated in the study. Data were collected at baseline and at three, six, nine and 12 months. Variables assessed were adherence, attitude, outcome expectancies, self-efficacy, patient satisfaction with the relationship with their physician, provision of social support, optimism, CD4 cell count, viral load and side effects. Predictors of adherence in the Generalized Estimated Equation (GEE) were: high perception of self-efficacy (OR=1.68; 95%CI 1.27-2.22), positive attitude towards taking medication (OR=1.56; 95%CI 1.18-2.06), not living alone (OR=1.47; 95%CI 1.04-2.08) and being a male (OR=2.81; 95%CI 1.47-5.34). Subsequent analysis showed that a positive attitude towards taking medication was associated with a high level of patient satisfaction with their physician, high perceived social support, being optimistic, living with HIV for five years or less and experiencing no side effects. Also, a strong sense of self-efficacy was associated with positive perception of social support, high level of patient satisfaction with their physician and not living alone. These results suggest that interventions aimed at improving adherence to ART should focus on reinforcing self-efficacy and developing a positive attitude towards taking medication.
机译：这项纵向研究的目的是确定在12个月内HIV患者坚持抗逆转录病毒疗法（ART）的决定因素。共有376名接受抗逆转录病毒疗法治疗的HIV感染者参加了该研究。在基线以及三个，六个，九个和十二个月时收集数据。评估的变量包括依从性，态度，结局预期，自我效能感，患者对其与医生的关系的满意度，社会支持的提供，乐观，CD4细胞计数，病毒载量和副作用。广义估计方程（GEE）中依从性的预测因素包括：自我效能感高（OR = 1.68; 95％CI 1.27-2.22）;对服药的积极态度（OR = 1.56; 95％CI 1.18-2.06），不单身生活（OR = 1.47; 95％CI 1.04-2.08），并且是男性（OR = 2.81; 95％CI 1.47-5.34）。随后的分析表明，对药物治疗的积极态度与患者对医生的高度满意，高度的社会支持感，乐观，感染艾滋病毒五年或更短且没有副作用有关。此外，强烈的自我效能感与对社会支持的积极认识，患者对医生的高度满意度以及不独自生活有关。这些结果表明，旨在改善对抗逆转录病毒疗法依从性的干预措施应着重于增强自我效能和对服用药物持积极态度。

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