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首页> 外文期刊>The Pediatric infectious disease journal >Viral Etiology of Acute Lower Respiratory Tract Infections in Hospitalized Children in Nagasaki, a Regional City of Japan in 2013-2015
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Viral Etiology of Acute Lower Respiratory Tract Infections in Hospitalized Children in Nagasaki, a Regional City of Japan in 2013-2015

机译：2013 - 2015年日本市区市长崎儿童住院儿童急性呼吸道感染病毒病程

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Background: Acute lower respiratory tract infections (ALRIs) are the most common disease for hospitalized children in Japan. The aim of this study was to identify viruses in children hospitalized for ALRIs and to demonstrate epidemiologic and clinical characteristics in Japan. Methods: During a 2-year period from February 2013 to January 2015, we collected nasopharyngeal swab specimens from almost all hospitalized children with ALRIs in Nagasaki, a regional city of Japan, and its environs. Viruses were detected by multiplex polymerase chain reaction from these samples. Results: We detected one or more viruses from 259 (69%) of 374 patients, 227 of whom were infected with a single virus, 30 with 2, and 2 with 3 viruses. Detected viruses in this study were rhinovirus (46.4%), respiratory syncytial virus (29.7%), human metapneumovirus (6.8%), parainfluenza virus (5.5%), enterovirus D68 (3.4%), influenza virus (2.7%), adenovirus (2.4%), bocavirus (2.0%) and Coxsackie virus (1.0%). We detected a seasonal shift in respiratory syncytial virus outbreaks from the 2013-2014 to the 2014-2015 seasons. There was no significant difference in clinical course and severity among those viruses. Patients with a history of asthma or underlying diseases were older and more frequently required oxygen therapy than previously healthy patients. Conclusions: Viral etiology in hospitalized children with ALRIs in Nagasaki, Japan, was similar to that in many other countries. Enterovirus D68, which was recently recognized as a causative agent of severe ALRIs, was also identified in this study area. Severity of ALRIs may depend on underlying disease rather than type of etiologic virus.
机译：背景：急性下呼吸道感染（ALRIS）是日本住院儿童最常见的疾病。本研究的目的是识别为Alris住院儿童的病毒，并在日本展示流行病学和临床特征。方法：2013年2月至2015年1月，我们从几乎所有住院儿童收集了Nagasaki，日本区域市及其周边地区的鼻咽拭子。通过来自这些样品的多重聚合酶链反应检测病毒。结果：我们检测到从259例（69％）的374名患者中的一种或多种病毒，其中227名患有单一病毒，30例，2和2例，其中3例有3个病毒。检测到本研究中的病毒是鼻病毒（46.4％），呼吸道合胞病毒（29.7％），人类术治病毒（6.8％），Parainfluenza病毒（5.5％），肠道病毒D68（3.4％），流感病毒（2.7％），腺病毒（ 2.4％），Bocavirus（2.0％）和Coxsackie病毒（1.0％）。我们检测到2013 - 2014年呼吸道合胞病毒爆发的季节性转变为2014-2015赛季。这些病毒的临床过程和严重程度没有显着差异。患有哮喘或潜在疾病史的患者年龄较大，更常见需要氧疗法而不是先前健康的患者。结论：日本长崎的住院儿童病毒病毒学与许多其他国家相似。在本研究区域还发现了最近被认为是严重ALRIS的致病剂的肠道病毒D68。 Alris的严重程度可能取决于潜在的疾病而不是类型的病因病毒。

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