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首页> 外文期刊>AIDS Research and Human Retroviruses >Changing rate of non-B subtypes and coinfection with hepatitis B/C viruses in newly diagnosed HIV type 1 individuals in Spain.
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Changing rate of non-B subtypes and coinfection with hepatitis B/C viruses in newly diagnosed HIV type 1 individuals in Spain.

机译：西班牙新诊断的1型HIV个​​体中非B亚型的发生率变化以及与B / C病毒共感染。

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摘要

Immigration from developing regions to Western countries has resulted in an increased rate of non-B subtypes in the HIV population. However, it is unclear whether these HIV variants remain confined to foreigners or are already spreading among natives. Since many immigrants come from regions in which hepatitis B virus (HBV) and hepatitis C virus (HCV) are endemic, HIV-hepatitis coinfection might be more frequent in newly diagnosed HIV persons. Herein, we report changes in the prevalence and distribution of HIV-1 subtypes in Madrid, Spain over the past 10 years as well as the rate of chronic HBV and HCV coinfection in 1854 newly diagnosed HIV-1 individuals. Overall 18.2% carried HIV-1 non-B subtypes, although the prevalence increased over time reaching a peak of 19.4% in the last period (2007-2010). The most common non-B variants were CRF02_AG (37%), G (12%), A (9.9%), and C (7.8%). In native Spaniards the rate of non-B subtypes increased from 1.5% in 2000-2002 to 7.2% in 2003-2006 and to 11.4% in 2007-2010 (p = 0.04). Chronic hepatitis B and C were found, respectively, in 4.2% and 8.3% of the study population. While the prevalence of chronic hepatitis B has remained fairly stable over time across distinct populations, the rate of chronic HCV infection has experienced a significant decline, mainly in native Spaniards as a result of a reduction in intravenous drug use. In summary, the prevalence of HIV-1 non-B subtypes is rising in newly diagnosed HIV-1 individuals in Spain, including the native population. In contrast, the rate of HBV coinfection remains unchanged and the rate of HCV coinfection has declined.
机译：从发展中地区向西方国家的移民导致艾滋病毒人群中非B亚型的比率增加。但是，目前尚不清楚这些艾滋病毒变体是仅局限于外国人还是已经在当地人中传播。由于许多移民来自乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）流行的地区，因此在新诊断的HIV感染者中，HIV-肝炎合并感染可能会更加频繁。本文中，我们报告了过去10年中西班牙马德里HIV-1亚型的流行和分布以及1854年新诊断的HIV-1个体中慢性HBV和HCV合并感染率的变化。总体上，有18.2％的人携带HIV-1非B型亚型，尽管流行率随时间增加，在上一个时期（2007-2010年）达到19.4％的峰值。最常见的非B变体是CRF02_AG（37％），G（12％），A（9.9％）和C（7.8％）。在本地西班牙人中，非B型亚型的比例从2000-2002年的1.5％增加到2003-2006年的7.2％和2007-2010年的11.4％（p = 0.04）。在研究人群中分别发现了慢性乙型和丙型肝炎，分别占4.2％和8.3％。尽管不同人群的慢性乙型肝炎流行率随时间保持稳定，但慢性HCV感染率已显着下降，主要是由于静脉注射毒品的减少导致的西班牙本地人。总之，在西班牙，包括当地居民在内，西班牙新诊断的HIV-1个体中HIV-1非B型亚型的患病率正在上升。相反，HBV合并感染率保持不变，HCV合并感染率下降。

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