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HTLV-2b among HIV type 1-coinfected injecting drug users in Spain.

机译：西班牙的HIV 1型感染注射吸毒者中的HTLV-2b。

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摘要

Human T cell lymphotropic virus type 2 (HTLV-2) infection is endemic in the American Indian population and Pygmy tribes in Africa. Nevertheless, HTLV-2 infection has been predominantly detected in U.S. and European injecting drug users (IDU). Noteworthy is that the HTLV-2a subtype is the main circulating variant in North America and Eastern Europe whereas the HTLV-2b subtype is mainly found in Western Europe, particularly in Italy and Spain where coinfection with HIV-1 is frequent. Twelve Spanish subjects infected with HTLV-2 were recruited for the study. All of them were IDUs coinfected with HIV-1. Molecular epidemiology was done by sequencing the LTR, env, and tax regions and by generating phylogenetic trees. The present study showed that all the sequences belonged to the HTLV-2b subtype and were closely related to other Spanish and Portuguese reported sequences, clearly differentiated from those belonging to the HTLV-2a subtype from Eastern Europe. Therefore, infection with HTLV-2b remains prevalent in Spain based on previous studies.
机译：人类T细胞2型淋巴病毒（HTLV-2）感染在美洲印第安人人群和非洲y格米人部落中流行。但是，在美国和欧洲注射吸毒者（IDU）中主要检测到HTLV-2感染。值得注意的是，HTLV-2a亚型是北美和东欧的主要循环变异体，而HTLV-2b亚型主要在西欧发现，特别是在频繁合并感染HIV-1的意大利和西班牙。招募了十二名感染HTLV-2的西班牙受试者进行研究。他们都是感染了HIV-1的IDU。分子流行病学是通过对LTR，env和tax区域进行测序并生成系统树来完成的。本研究表明，所有序列均属于HTLV-2b亚型，并且与其他西班牙和葡萄牙报道的序列密切相关，与东欧的HTLV-2a亚型明显不同。因此，根据先前的研究，HTLV-2b的感染在西班牙仍然很普遍。

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