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首页> 外文期刊>Therapeutic apheresis and dialysis: official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy >FGF23 Level and Intima-Media Thickness Are Elevated From Early Stages of Chronic Kidney Disease
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FGF23 Level and Intima-Media Thickness Are Elevated From Early Stages of Chronic Kidney Disease

机译：FGF23水平和内部介质厚度从慢性肾病的早期阶段升高

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摘要

Considering high cardiovascular (CV) risk in chronic kidney disease (CKD), the aim of this cross-sectional study was to assess the association between carotid intima-media thickness (IMT) and fibroblast growth factor (FGF) 23 as important players in CV pathophysiology. Eighty-seven patients with mean estimated glomerular filtration rate 40.1mL/min per 1.73m(2) were involved. FGF23 and IMT were elevated from early stages of CKD. Mean IMT value was 1.10 +/- 0.20mm, being significantly elevated starting from early CKD, showing no correlation with FGF23 (r=-0.01, P=-0.91). Unlike the FGF23 level that followed worsening of kidney function, IMT was increasing only in the initial CKD stages, with no further increase from CKD stage 3 on. Although we found no direct association between current use of vitamin D and statin therapy, this may be associated with the sustained reference values of lipid and vitamin D status under treatment that further preclude worsening of IMT in patients with advanced CKD.
机译：考虑到慢性肾病（CKD）中的高心血管（CV）风险，这种横截面研究的目的是评估颈动脉内膜厚度（IMT）和成纤维细胞生长因子（FGF）23之间的关联作为CV中的重要参与者病理生理学。涉及八十七名平均估计肾小球过滤速率40.1ml / min。 FGF23和IMT从CKD的早期阶段升高。平均IMT值为1.10 +/- 0.20mm，从早期CKD开始显着升高，显示与FGF23（R = -0.01，P = -0.91）没有相关性。与肾功能下降的FGF23水平不同，IMT仅在初始CKD阶段增加，而不从CKD第3阶段进一步增加。虽然我们发现目前使用维生素D和他汀类药物治疗之间的直接关联，但这可能与治疗过程中脂质和维生素D状态的持续参考值相关联，以进一步妨碍IMT在高级CKD患者中的恶化。

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