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Different oral cancer scenarios to personalize targeted therapy: Boron Neutron Capture Therapy translational studies

机译:不同的口腔癌情景个性化靶向治疗:硼中子捕获治疗转化研究

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摘要

Boron neutron capture therapy (BNCT) is a targeted therapy, which consists of preferential accumulation of boron carriers in tumor followed by neutron irradiation. Each oral cancer patient has different risks of developing one or more carcinomas and/or oral mucositis induced after treatment. Our group proposed the hamster oral cancer model to study the efficacy of BNCT and associated mucositis. Translational studies are essential to the advancement of novel boron delivery agents and targeted strategies. Herein, we review our work in the hamster model in which we studied BNCT-induced mucositis using three different cancerization protocols, mimicking three different clinical scenarios. The BNCT-induced mucositis increases with the aggressiveness of the carcinogenesis protocol employed, suggesting that the study of different oral cancer patient scenarios would help to develop personalized therapies.
机译:硼中子捕获治疗(BNCT)是靶向治疗,其包括在肿瘤中的硼载体的优先积累,然后是中子辐射。 每个口腔癌患者在治疗后发育一种或多种癌和/或口服粘膜炎的风险不同。 我们的小组提出了仓鼠口腔癌模型研究BNCT和相关粘膜炎的疗效。 翻译研究对于新型硼递送剂和有针对性的策略的进步至关重要。 在此,我们在使用三种不同的癌症方案中研究了我们研究了BNCT诱导的粘膜炎的仓鼠模型中的工作,模仿了三种不同的临床情景。 BNCT诱导的粘膜炎随着致癌方案的侵略性增加,表明对不同口腔癌症患者情景的研究将有助于培养个性化疗法。

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