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首页> 外文期刊>AIDS Research and Human Retroviruses >Ankle brachial index screening for occult vascular disease is not useful in HIV-positive patients.
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Ankle brachial index screening for occult vascular disease is not useful in HIV-positive patients.

机译：隐匿性血管疾病的踝臂指数筛查在HIV阳性患者中没有用。

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Metabolic complications common to the HIV-positive population may increase the risk for cardiovascular disease. Asymptomatic peripheral arterial disease (PAD) is associated with increased cardiovascular risk. The ankle-brachial pressure index (ABI) is a screening tool commonly used for the detection of asymptomatic PAD. The prevalence of asymptomatic PAD based on ABI in HIV-positive patients is unknown. This study was cross-sectional in design and assessed PAD by measuring the systolic ABI as determined by a handheld 8-MHz Doppler probe with the patient at rest in a supine position. A brief medical history including pertinent risk factors was obtained. One hundred and sixty-seven HIV-positive patients were evaluated (97.6% male; mean age 52.0 years; 31.2% current smokers, 29.4% former smokers, 26.3% diabetes mellitus). Asymptomatic PAD (ABI < or = 0.9) was found in four patients (2.4%, 95% CI: 0.3-4.5%). Smoking was a significant predictor of PAD. Patients with a positive test for PAD had at least two major risk factors for the disease including smoking, a history of disease in another vascular bed, dyslipidemia, diabetes, and hypertension. All patients with a positive test for PAD had a high risk (>20%) for cardiovascular disease according to the Framingham risk score. Three of the four patients with positive tests had previously diagnosed vascular disease (CAD, stroke). Three patients presenting with PAD were evaluated and all had a positive ABI. The prevalence of PAD compared to previous studies on PAD in HIV was low and identified only those patients with high cardiovascular risk based on other features. ABI was not useful in detecting occult vascular disease in HIV-positive patients and offers no additional information to that derived from cardiovascular risk stratification.
机译：HIV阳性人群常见的代谢并发症可能会增加心血管疾病的风险。无症状的外周动脉疾病（PAD）与心血管风险增加有关。踝肱压力指数（ABI）是一种筛查工具，通常用于检测无症状的PAD。基于ABI的无症状PAD在HIV阳性患者中的患病率尚不清楚。本研究为横断面设计，通过测量收缩期ABI评估PAD，该收缩期ABI是由手持式8 MHz多普勒探头确定的，患者处于仰卧位。获得了简短的病历，包括相关的危险因素。对167例HIV阳性患者进行了评估（男性97.6％;平均年龄52.0岁;当前吸烟者31.2％，以前吸烟者29.4％，糖尿病26.3％）。在四名患者中发现无症状PAD（ABI <或= 0.9）（2.4％，95％CI：0.3-4.5％）。吸烟是PAD的重要预测指标。 PAD检测呈阳性的患者至少有两个主要的疾病危险因素，包括吸烟，另一血管病史，血脂异常，糖尿病和高血压。根据Framingham风险评分，所有PAD呈阳性的患者都具有较高的心血管疾病风险（> 20％）。接受阳性测试的四名患者中有三名先前已诊断出血管疾病（CAD，中风）。对三名PAD患者进行了评估，所有患者的ABI均为阳性。与先前有关HIV中PAD的研究相比，PAD的患病率低，并且仅基于其他特征确定了那些具有高心血管风险的患者。 ABI在检测HIV阳性患者的隐匿性血管疾病方面无用，对于心血管疾病风险分层所提供的信息没有提供更多信息。

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