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首页> 外文期刊>AIDS Research and Human Retroviruses >Genome sequence of a novel HIV-1 circulating recombinant form (CRF64-BC) identified from Yunnan, China
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Genome sequence of a novel HIV-1 circulating recombinant form (CRF64-BC) identified from Yunnan, China

机译：从中国云南鉴定的新型HIV-1循环重组形式（CRF64-BC）的基因组序列

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摘要

We report a novel HIV-1 circulating recombinant form (CRF64-BC) that was isolated from five epidemiologically unlinked HIV-infected persons in Yunnan province. CRF64-BC was composed of subtype B and subtype C, with five short subtype B segments inserted into the subtype C backbone. Phylogenetic analysis demonstrated that the C subregion was correlated with the India C lineage, which was transmitted into China in the early 1990s. The evolutionary history of the B subregion was not as clear as the C subregion, as the short length of this region yielded poor phylogenetic results. Dehong is considered the epicenter of HIV-1 in China, and recombinant strains such as CRF07-BC and CRF08-BC, which also originated from this region, have spread widely in China. The newly emerged CRF64-BC increases the complexity of the HIV epidemic in China and complicates the development of subtype-specific tools against HIV transmission.
机译：我们报告了一种新型的HIV-1循环重组形式（CRF64-BC），它是从云南省的五个流行病学无关的HIV感染者中分离出来的。 CRF64-BC由B型和C型组成，五个短的B型短片段插入C型主链。系统发育分析表明，C子区域与印度C谱系相关，后者在1990年代初被传入中国。 B子区域的进化历史不如C子区域清晰，因为该区域的长度短导致系统发育结果差。德宏被认为是中国HIV-1的震中地带，同样起源于该地区的重组菌株如CRF07-BC和CRF08-BC也已在中国广泛传播。新近出现的CRF64-BC增加了中国HIV流行的复杂性，并使针对HIV传播的亚型专用工具的开发变得复杂。

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