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首页> 外文期刊>AIDS Research and Human Retroviruses >Near full-length sequence analysis of a novel HIV-1 C/CRF01_AE recombinant variant from Yunnan, China.
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Near full-length sequence analysis of a novel HIV-1 C/CRF01_AE recombinant variant from Yunnan, China.

机译：来自中国云南的新型HIV-1 C / CRF01_AE重组变异体的近全长序列分析。

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摘要

Recombination contributes substantially to the overall genetic complexity of HIV-1, especially in populations in which multiple subtypes circulate. Yunnan is a province in China with most severely HIV epidemic where many subtypes and CRFs of HIV-1 are circulating. In this study, we report a novel HIV-1 recombination involving C and CRF01_AE. The near full-length genome was reverse transcripted and amplified in two halves with the 1 kb overlap regions. The PCR products were sequenced directly after purification. Sequence analysis showed that the majority of the genome was CRF01_AE, three fragments of C subtype were inserted along the genome in gag and pol region. This is the first report of a novel recombination involving subtype C and CRF01_AE in Yunnan, China. More work is needed to check the epidemiologic significance of the new recombination.
机译：重组在很大程度上导致了HIV-1的总体遗传复杂性，特别是在有多种亚型传播的人群中。云南是中国艾滋病毒流行最严重的省份，许多HIV-1的亚型和CRF正在传播。在这项研究中，我们报告了涉及C和CRF01_AE的新型HIV-1重组。将近乎全长的基因组进行逆转录，并以两个半部分的1 kb重叠区域进行扩增。纯化后直接对PCR产物进行测序。序列分析表明，该基因组的大部分为CRF01_AE，在gag和pol区沿基因组插入了三个C亚型片段。这是在中国云南涉及C型和CRF01_AE的新型重组的首次报道。需要更多的工作来检查新重组的流行病学意义。

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