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首页> 外文期刊>AIDS Research and Human Retroviruses >Antiretroviral resistance among HIV type 1-infected women first exposed to antiretrovirals during pregnancy: plasma versus PBMCs.
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Antiretroviral resistance among HIV type 1-infected women first exposed to antiretrovirals during pregnancy: plasma versus PBMCs.

机译：在怀孕期间首次暴露于抗逆转录病毒药物的HIV 1型感染妇女中，抗逆转录病毒的抵抗力：血浆与PBMC。

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Resistance-associated mutations (RAMs) in plasma samples from HIV-1-infected women who received antiretroviral (ARV) prophylaxis during pregnancy was assessed and correlated with the detection of RAMs in peripheral blood mononuclear cells (PMBCs). The study population was composed of HIV-1-infected women enrolled in a prospective cohort study in Latin America and the Caribbean (NISDI Perinatal Study) as of March 1, 2005, who were diagnosed with HIV-1 infection during the current pregnancy, who received ARVs during pregnancy for prevention of mother-to-child transmission of HIV-1, and who were followed through at least the 6-12 week postpartum visit. Plasma samples collected at enrollment during pregnancy and at 6-12 weeks postpartum were assayed for RAMs. Plasma results were compared to previously described PBMC results from the same study population. Of 819 enrolled subjects, 197 met the eligibility criteria. Nucleic acid amplification was accomplished in 123 plasma samples at enrollment or 6-12 weekspostpartum, and RAMs were detected in 22 (17.9%; 95%CI: 11.7-25.9%). Previous analyses had demonstrated detection of RAMs in PBMCs in 19 (16.1%). There was high concordance between RAMs detected in plasma and PBMC samples, with only eight discordant pairs. The prevalence of RAMs among these pregnant, HIV-1-infected women is high (15%). Rates of detection of RAMs in plasma and PBMC samples were similar.
机译：评估了在怀孕期间接受抗逆转录病毒（ARV）预防的HIV-1感染妇女血浆样品中的耐药相关突变（RAM），并将其与外周血单个核细胞（PMBC）中RAM的检测相关联。该研究人群由截至2005年3月1日在拉丁美洲和加勒比地区进行的前瞻性队列研究（NISDI围产期研究）中被HIV-1感染的妇女组成，她们在当前怀孕期间被诊断出感染HIV-1。孕妇在怀孕期间接受了抗逆转录病毒疗法以防止母婴传播HIV-1，并且至少在产后6-12周内接受了随访。分析在怀孕期间和产后6-12周时收集的血浆样本的RAM。将血浆结果与先前描述的来自同一研究人群的PBMC结果进行比较。在819名入学受试者中，有197名符合资格标准。在入组时或产后6-12周内，在123个血浆样品中完成了核酸扩增，在22个样品中检出了RAM（17.9％; 95％CI：11.7-25.9％）。先前的分析表明，有19例（16.1％）的PBMC中存在RAM。血浆和PBMC样品中检测到的RAM之间存在高度一致性，只有八对不一致。在这些感染了HIV-1的孕妇中，RAM的患病率很高（15％）。血浆和PBMC样品中RAM的检出率相似。

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