Near full-length genome identification of a novel HIV-1 recombinant form (CRF01-AE/B′/C) among heterosexuals in Jilin, China

LiX.; NingC.; ChenY.; FengY.; WeiM.; XingH.; ShaoY.

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Near full-length genome identification of a novel HIV-1 recombinant form (CRF01-AE/B′/C) among heterosexuals in Jilin, China

机译：吉林省异性恋者中一种新型HIV-1重组形式（CRF01-AE / B'/ C）的近全长基因组鉴定

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Recombinant forms contribute significantly to the genetic diversity of HIV-1. Here we report a novel HIV-1 recombinant form (CRF01-AE/B′/C) detected from a comprehensive HIV-1 molecular epidemiologic study among heterosexuals in Jilin province of northeastern China. Recombinant analyses of the near full-length genome (NFLG) of the novel HIV-1 recombinant isolate (JL.RF01) showed that the backbone of the genome was CRF01-AE, and three insertions of subtype B′ (242, 370, and 233bp) and C (1142, 230, and 271bp), respectively, were inserted along the genome. Phylogenetic analyses revealed that the novel HIV-1 recombinant form (CRF01-AE/B′/C) more likely originated from Thailand subtype B′ and CRF01-AE and India subtype C. We report a unique mosaic structure that is distinct to HIV-1 CRF01-AE/B′/C recombinant viruses reported to date. The emergence of this novel recombinant form (CRF01-AE/B′/C) suggests the increasing significance of heterosexual transmission contributing to the complexity of the HIV-1 epidemic in northeastern China.

机译：重组形式极大地促进了HIV-1的遗传多样性。在这里，我们报告从中国东北吉林省的异性恋者中进行的全面HIV-1分子流行病学研究检测到的一种新型HIV-1重组形式（CRF01-AE / B'/ C）。对新型HIV-1重组分离物（JL.RF01）的近全长基因组（NFLG）的重组分析表明，基因组的骨架为CRF01-AE，并插入了三个B型亚型（242、370和沿着基因组分别插入了233bp）和C（1142、230和271bp）。系统发育分析表明，新型HIV-1重组形式（CRF01-AE / B'/ C）更有可能源自泰国B'型和CRF01-AE以及印度C型。我们报道了一种独特的镶嵌结构，与HIV-迄今为止报道了1种CRF01-AE / B'/ C重组病毒。这种新型重组形式（CRF01-AE / B'/ C）的出现表明，异性传播的重要性日益增加，导致中国东北地区HIV-1流行病的复杂性。

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《AIDS Research and Human Retroviruses》 |2014年第7期|共6页
作者
LiX.; NingC.; ChenY.; FengY.; WeiM.; XingH.; ShaoY.;
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1. Near full-length genome identification of a novel HIV-1 recombinant form (CRF01-AE/B′/C) among heterosexuals in Jilin, China [J] . LiX., NingC., ChenY., AIDS Research and Human Retroviruses . 2014,第7期

机译：吉林省异性恋者中一种新型HIV-1重组形式（CRF01-AE / B'/ C）的近全长基因组鉴定
2. Near full-length genome sequence of a Novel HIV Type 1 second-generation recombinant form (CRF01-AE/CRF07-BC) identified among men who have sex with men in Jilin, China [J] . LiX., NingC., HeX., AIDS Research and Human Retroviruses . 2013,第12期

机译：在吉林省与男性发生性行为的男性中鉴定出新型HIV 1型第二代重组体（CRF01-AE / CRF07-BC）的近全长基因组序列
3. Near full-length genome characterization of a new CRF01-AE/CRF08-BC recombinant transmitted between a heterosexual couple in Guangxi, China [J] . WangN., WeiH., XiongR., AIDS Research and Human Retroviruses . 2014,第5期

机译：在中国广西的异性恋夫妇之间传播的新型CRF01-AE / CRF08-BC重组体的近全长基因组表征
4. Classifying HIV-1 Circulating Recombinant Forms [C] . A. Steven Eliuk, B. Keith Ruiter, C. Pierre Boulanger International Conference on Bioinformatics Computational Biology . 2011

机译：分类HIV-1循环重组形式
5. Identification of a large set of single copy orthologous genes (COSII) across euasterid species by combining bioinformatics and phylogenetics and a study of genome evolution in the family Solanaceae in a phylogenetic context [D] . Wu, Feinan 2007

机译：通过结合生物信息学和系统发育学以及研究茄科中茄科的基因组进化研究，在整个泛型物种中鉴定了一大套单拷贝直系同源基因（COSII）
6. Near Full-Length Genome Identification of a Novel HIV-1 Recombinant Form (CRF01_AE/B′/C) Among Heterosexuals in Jilin China [O] . Xingguang Li, Chuanyi Ning, Yanli Chen, -1

机译：吉林省异性恋者中一种新型HIV-1重组形式（CRF01_AE / B/ C）的近全长基因组鉴定。
7. Near Full-Length Genome Identification of a Novel HIV Type 1 B′/C Recombinant Isolate JL100091 in Jilin, China [O] . Chuanyi Ning, Xingguang Li, Xiang He, 2013

机译：吉林省新型HIV型1 B'/ C重组分离jL100091的全长基因组鉴定近全长基因组鉴定

Near full-length genome identification of a novel HIV-1 recombinant form (CRF01-AE/B′/C) among heterosexuals in Jilin, China

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