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首页> 外文期刊>AIDS Research and Human Retroviruses >Near Full-Length Genomic Characterization of a Novel CRF 01_AE/C Recombinant from Western India
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Near Full-Length Genomic Characterization of a Novel CRF 01_AE/C Recombinant from Western India

机译：印度西部新型CRF 01_AE / C重组子的近全长基因组表征

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摘要

HIV is known for its genetic variability across the globe. The HIV epidemic in India is primarily driven by subtype C, although sporadic circulating and unique recombinant forms are also reported from a few metropolitan cities in which genotyping facilities are available. Here we report a novel CRF01_AE/C recombinant from a multicenter study on the effectiveness of antiretroviral therapy (ART), 12 months after its initiation. Our subject is a 32-year-old heterosexual female, a native of Pune city in western India. Identification and analyses of recombination breakpoints using jpHMM@Gobics and SimPlot bootscanning revealed six recombination breakpoints, indicating insertion of the CRF01_AE genome at three points in the backbone of subtype C. Both subtype C and CRF01_AE are commonly seen in the population at risk of heterosexual HIV transmission, thereby providing an opportunity for cocirculation and recombination. The emergence of a novel recombinant of CRF01_AE/C is indicative of the increasing genetic diversity of the HIV epidemic in India.
机译：HIV以其全球遗传变异性而闻名。印度的艾滋病毒流行主要由C型引起，尽管也有少数具有基因分型设施的大城市也报告了零星的流行和独特的重组形式。在这里，我们报告了从抗逆转录病毒疗法（ART）生效后12个月的多中心研究中得出的新型CRF01_AE / C重组体。我们的受试者是一名32岁的异性恋女性，她是印度西部浦那市的本地人。使用jpHMM @ Gobics和SimPlot bootscanning进行的重组断裂点的鉴定和分析揭示了6个重组断裂点，表明CRF01_AE基因组插入了C亚型骨干中的三个点。传播，从而提供了循环和重组的机会。新型CRF01_AE / C重组体的出现表明印度HIV流行的遗传多样性不断增加。

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