Raltegravir and etravirine are active against HIV type 1 group O.

Briz V; Garrido C; Poveda E; Morello J; Barreiro P; de-Mendoza C; Soriano V

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Raltegravir and etravirine are active against HIV type 1 group O.

机译：Raltegravir和etravirine对HIV 1型O组具有活性。

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Abstract The activity of raltegravir and etravirine was assessed in vitro in HIV-1 group O isolates. Despite the presence of some natural polymorphisms associated with resistance to raltegravir (V72I, L74I, S153A, V201I, and T206S) and etravirine (G190A), both drugs showed significant antiviral activity. Subsequently, the clinical benefit was shown in an HIV-1 group O-infected individual in whom enfuvirtide was replaced by raltegravir. Therefore, individuals infected with HIV-1 group O might benefit from raltegravir and/or etravirine therapy.

机译：摘要评价了HIV-1 O型分离株中raltegravir和etravirine的活性。尽管存在与拉格韦（V72I，L74I，S153A，V201I和T206S）和依曲韦林（G190A）耐药相关的某些自然多态性，但两种药物均显示出显着的抗病毒活性。随后，在HIV-1组被O感染的个体中显示了临床益处，其中恩夫韦肽被拉格替韦替代。因此，感染HIV-1 O组的个体可能会从raltegravir和/或etravirine治疗中受益。

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来源
《AIDS Research and Human Retroviruses》 |2009年第2期|共3页
作者
Briz V; Garrido C; Poveda E; Morello J; Barreiro P; de-Mendoza C; Soriano V;
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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
Amino Acid Substitution; Anti-HIV Agents; Drug Resistance; Viral; Female; 氨基酸取代; 抗HIV药; HIV感染; 突变; 误义; 哒嗪类; 吡咯烷酮类; RNA; 病毒;

机译：Amino Acid Substitution;Anti-HIV Agents;Drug Resistance;Viral;Female;氨基酸取代;抗HIV药;HIV感染;突变;误义;哒嗪类;吡咯烷酮类;RNA;病毒;

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1. Raltegravir and etravirine are active against HIV type 1 group O. [J] . Briz V, Garrido C, Poveda E, AIDS Research and Human Retroviruses . 2009,第2期

机译：Raltegravir和etravirine对HIV 1型O组具有活性。
2. Raltegravir and Etravirine Are Active against HIV Type 1 Group O [J] . Verónica Briz, Carolina Garrido, Eva Poveda, AIDS Research and Human Retroviruses . 2009,第2期

机译：Raltegravir和Etravirine对HIV 1型O组具有活性
3. Potent and sustained antiviral response of raltegravir-based highly active antiretroviral therapy in HIV type 1-infected children and adolescents [J] . BrizV., León-LealJ.A., PalladinoC., The Pediatric infectious disease journal . 2012,第3期

机译：基于raltegravir的高效抗逆转录病毒疗法在感染了1型HIV的儿童和青少年中的有效且持续的抗病毒反应
4. An I-D. O. F. controlled attraction type magnetic bearing [C] . Da Silva, I., Horikawa, . 1999

机译：I-D。 O.F.控制吸引式电磁轴承
5. Validation of a UPLC-MS/MS method for the simultaneous measurement of the antiretroviral drugs atazanavir, darunavir, efavirenz, etravirine, lopinavir, raltegravir, ritonavir from human plasma. [D] . Patel, Rutva. 2012

机译：用于从人血浆中同时测定抗逆转录病毒药物阿扎那韦，达鲁那韦，依非韦伦，依曲韦林，洛匹那韦，拉格列韦，利托那韦的UPLC-MS / MS方法的验证。
6. Maintenance of Viral Suppression after Optimization Therapy from Etravirine Plus Raltegravir to Rilpivirine Plus Dolutegravir in HIV-1-Infected Patients [O] . Niccolò Riccardi, Filippo Del Puente, Lucia Taramasso, 2019

机译：在HIV-1感染的患者中从伊曲韦林加拉尔格韦到瑞吡韦林加多卢格韦的优化治疗后维持病毒抑制
7. PIN61 Cost of Virologic Response with Two Active Drugs in the Optimized Background Therapy with Etravirine, Raltegravir, and Maraviroc in the Brazilian National AIDS Program [O] . Morais A.D., Pereira M.L., Azevedo H. 2011

机译：在巴西国家艾滋病项目中，采用依曲韦林，拉尔格韦和马拉维罗克对最佳背景疗法进行最佳背景治疗时，使用两种活性药物进行病毒学应答的PIN61成本

Raltegravir and etravirine are active against HIV type 1 group O.

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