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首页> 外文期刊>Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research >Nanoparticle-rich diesel exhaust may disrupt testosterone biosynthesis and metabolism via growth hormone
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Nanoparticle-rich diesel exhaust may disrupt testosterone biosynthesis and metabolism via growth hormone

机译：富含纳米粒子的柴油机可能会通过生长激素破坏睾酮生物合成和代谢

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We previously reported that exposure to low (22.5+-0.2nm in diameter, 15.4+-l.Cmug/m~3 in mass weight, 2.27Xl0~5/cm~3 in mean number concentration), and medium (26.1 +-0.5 nm, 36.4+- 1.2 μg/m3, 5.11 X10~5/cm~3) concentrations of nanoparticle-rich diesel exhaust (NR-DE) for 1 and 2 months (5 h/day, 5 days/week) significantly increased plasma testosterone in male Fischer 344 rats, whereas exposure to a high concentration (27.1 +-0.5nm, 168.8+-2.7 mug/m~3, 1.36X10~6/cm~3) did not. The present study attempts to clarify the mechanism of this elevation. Low and medium exposures to NR-DE for 1 and 2 months significantly increased steroidogenic acute regulatory protein (StAR)- and cytochrome P450 side-chain cleavage (P450scc)-mRNA and their protein expressions in the testis of rats, in which the elevation pattern was very similar to that of plasma testosterone levels. Interestingly, both exposure levels for 1 month significantly increased growth hormone (GH) receptor expression in the testis, and low exposure also increased testicular insulin-like growth factor I-mRNA levels and hepatic microsomal cytochrome P450 2C11-mRNA and their protein levels in rats. These two factors are thought to be related to growth hormone secretion. Disruption of testosterone biosynthesis by NR-DE exposure may be a mode of action for reproductive toxicity, which may, in part, be regulated by increasing StAR and P450scc expressions via GH signalling.
机译：我们之前报道的是暴露于低（直径为22.5±0.2nm，15.4 + -1.Cmug / m〜3质量重量，平均数浓度为2.27xl0〜5 / cm〜3），中等（26.1 + - 0.5nm，36.4 + - 1.2μg/ m 3,5.11 x10〜5 / cm〜3）浓度富含富含柴油排气（NR-de）的浓度为1和2个月（5 h /天，5天/周）显着增加血浆睾酮344大鼠，而暴露于高浓度（27.1 + -0.5nm，168.8 + -2.7 mug / m〜3，1.36x10〜6 / cm〜3）没有。本研究试图澄清该高度的机制。 NR-DE的低和中等暴露于1和2个月，显着增加了类化急性调节蛋白（星） - 和细胞色素P450侧链切割（P450SCC）-mRNA及其在大鼠睾丸中的蛋白质表达，其中升降模式与血浆睾酮水平非常相似。有趣的是，1个月的暴露水平显着增加了睾丸中的生长激素（GH）受体表达，低暴露也增加了睾丸状胰岛素样生长因子I-mRNA水平和肝微粒体细胞色素P450 2C11-mRNA及其蛋白质水平的大鼠。这两个因素被认为与生长激素分泌有关。 NR-De暴露的睾酮生物合成的破坏可以是生殖毒性的作用方式，其可以部分地通过GH信号传递增加星和P450SCC表达来调节。

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