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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Glucose-6-phosphate dehydrogenase deficient variants are associated with reduced susceptibility to malaria in the Brazilian Amazon.
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Glucose-6-phosphate dehydrogenase deficient variants are associated with reduced susceptibility to malaria in the Brazilian Amazon.

机译：葡萄糖-6-磷酸脱氢酶缺乏变体与巴西亚马逊的疟疾敏感性降低有关。

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Glucose-6-phosphate dehydrogenase deficiency (G6PDd) has been shown to protect against malaria infection and severe manifestations in African and Asia, but there is a scarcity of studies in the Americas. This study aimed to study the prevalence of G6PDd and its association with malaria occurrence in the Brazilian Amazon.A cross-sectional study was conducted in the male population to estimate the prevalence of G6PDd and malaria infection. G6PD deficient samples were genotyped to identify the deficient variant. Number of previous malaria episodes and need for blood transfusion during malaria episodes were recorded by applying a standardized questionary.From a sample of 1478 male individuals, 66 were detected as G6PD deficient, resulting in a prevalence of of 4.5% (95% CI = 3.44-5.56%). Fifty six G6PD deficient individuals (3.8%; 95% CI = 2.82-4.77) presented the G6PD A-variant mutation, while 10 individuals (0.7%; 95% CI = 0.42-0.97) severely deficient were genotyped as carriers of the G6PD Mediterranean variant. After adjusting for age, G6PD deficient individuals were less likely to report the occurrence of malaria episodes, and the protective effect was related to the enzyme activity, with carriers of the GG6PD A-variant presenting a 88% reduction (AOR: 0.119; 95% CI = 0.057-0.252; p < 0.001) and carriers of the Meditarrenean variant presenting 99% lower risk (AOR: 0.010; 95% CI = 0.002-0.252; p < 0.001) when compared to non-deficient individuals. On the other hand, G6PD deficient subjects reported higher need of transfusion during malaria episodes (p < 0.001).G6PD enzyme activity was directly related to susceptibility to malaria in the Brazilian Amazon, where P. vivax predominates. Severe G6PDd was associated with considerable higher risk of malaria-related transfusions.
机译：葡萄糖-6-磷酸脱氢酶缺乏（G6PDD）已被证明是为了防止非洲和亚洲的疟疾感染和严重表现，但美洲的研究略有稀缺。本研究旨在研究G6PDD的患病率及其与巴西亚马逊疟疾发生的关联。在男性人群中进行了横截面研究，估计了G6PDD和疟疾感染的患病率。 G6PD缺陷样本是基因分型以鉴定缺陷的变体。通过施加标准化质量记录先前疟疾事件的数量和对疟疾剧集期间的输血。通过施用1478名雄性个体的样品，检测为G6PD缺陷，导致4.5％的患病率（95％CI = 3.44 -5.56％）。五十六个G6PD缺乏个体（3.8％; 95％CI = 2.82-4.77）呈现了G6PD A-变异突变，而10个个体（0.7％; 95％CI = 0.42-0.97）是严重缺陷的，作为G6PD地中海的载体是基因分为缺陷变体。调整年龄后，G6PD缺乏的个体不太可能报告疟疾事件的发生，并且保护作用与酶活性有关，GG6PD A变异载体呈现88％的变异（AOR：0.119; 95％与非缺乏个体相比，CI = 0.057-0.252; p <0.001）和Meditarrenean变体的载体，其风险下降99％; 0.010; 95％Ci = 0.002-0.252; p <0.001）。另一方面，G6PD缺陷的受试者报告疟疾发作期间输血需要更高（P <0.001）.g6PD酶活性与巴西亚马逊的疟疾敏感性直接相关，其中P.Vivax占主导地位。严重的G6PDD与疟疾相关输血的风险相当有关。

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