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首页> 外文期刊>AIDS Research and Human Retroviruses >A Rapid Expansion of HIV-1 CRF63_02A1 Among Newly Diagnosed HIV-Infected Individuals in the Tomsk Region, Russia
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A Rapid Expansion of HIV-1 CRF63_02A1 Among Newly Diagnosed HIV-Infected Individuals in the Tomsk Region, Russia

机译：俄罗斯托木斯克州新诊断的HIV感染者中HIV-1 CRF63_02A1的迅速扩增

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摘要

The prevalence of HIV infection in different Russian regions is nonuniform. In the Tomsk region (TR), 2020 HIV new infection cases were recorded in 2013, the morbidity having increased 5.9-fold as compared to 2012. In total, 64 blood plasma samples from primary HIV cases have been examined. HIV-specific fragments of the pol gene have been obtained for 61 samples (of protease for 58 and of integrase for 23) and of the env gene V3 region for 40 samples. Phylogenetic analysis of the determined HIV-1 sequences has detected CRF63_02A1 in 55 (90.2%) cases, whereas HIV subtype A1, characteristic of Russia, has been observed in only three (4.9%) patients. Three (4.9%) cases contain CRF63_02A1/A recombinant variants. This article demonstrates that a drastic activation of the epidemic in the Tomsk region is accompanied by a rapid spreading of the recently described HIV-1 CRF63_02A1, which we detected in the Novosibirsk region outbreak of 2008.
机译：俄罗斯不同地区的艾滋病毒感染率不统一。在托木斯克州（TR），2013年记录了2020年的艾滋病毒新感染病例，与2012年相比，发病率增加了5.9倍。总共检查了64例来自原发性HIV病例的血浆样本。已获得61个样品的pol基因的HIV特异性片段（蛋白酶为58个，整合酶的为23个），env基因V3区的40个样品。对确定的HIV-1序列进行系统发育分析已在55（90.2％）例中检测到CRF63_02A1，而仅在三名（4.9％）患者中观察到了俄罗斯特有的HIV亚型A1。三（4.9％）例包含CRF63_02A1 / A重组变异体。本文证明，在托木斯克州，该流行病的剧烈活化伴随着最近描述的HIV-1 CRF63_02A1的迅速传播，我们在2008年的新西伯利亚地区爆发了这种病毒。

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