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Protein Acetylation and Its Role in Bacterial Virulence

机译:蛋白质乙酰化及其在细菌毒力中的作用

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摘要

Protein acetylation is a universal post-translational modification which is found in both eukaryotes and prokaryotes. This process is achieved enzymatically by the protein acetyltransferase Pat, and nonenzymatically by metabolic intermediates (e.g., acetyl phosphate) in bacteria. Protein acetylation plays a role in bacterial chemotaxis, metabolism, DNA replication, and other cellular processes. Recently, accumulating evidence has suggested that protein acetylation might be involved in bacterial virulence because a number of bacterial virulence factors are acetylated. In this review, we summarize the progress in understanding bacterial protein acetylation and discuss how it mediates bacterial virulence.
机译:蛋白质乙酰化是一种通用的翻译后修饰,其在真核生物和原核生物中发现。 该方法是通过蛋白质乙酰转移酶酶促酶,并通过细菌中代谢中间体(例如乙酰磷酸)的代谢中间体(例如,乙酰酯)来实现。 蛋白质乙酰化在细菌趋化性,代谢,DNA复制和其他细胞过程中起着作用。 最近,积累的证据表明蛋白质乙酰化可能涉及细菌毒力,因为许多细菌毒力因子是乙酰化的。 在本综述中,我们总结了了解细菌蛋白乙酰化的进展,并讨论它如何介导细菌毒力。

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  • 来源
    《Trends in Microbiology》 |2017年第9期|共12页
  • 作者单位

    Shanghai Jiao Tong Univ Sch Med Inst Med Sci Lab Bacterial Pathogenesis Dept Microbiol &

    Immun Shanghai 200025 Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Inst Med Sci Lab Bacterial Pathogenesis Dept Microbiol &

    Immun Shanghai 200025 Peoples R China;

    Shanghai Ruijin Hosp Dept Infect Dis Shanghai 200025 Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Inst Med Sci Lab Bacterial Pathogenesis Dept Microbiol &

    Immun Shanghai 200025 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 微生物学;
  • 关键词

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