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Classification of Midbrain Dopamine Neurons Using Single-Cell Gene Expression Profiling Approaches

机译:使用单细胞基因表达分析方法进行中脑多巴胺神经元的分类

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Dysfunctional dopamine (DA) signaling has been associated with a broad spectrum of neuropsychiatric disorders, prompting investigations into how midbrain DA neuron heterogeneity may underpin this variety of behavioral symptoms. Emerging literature indeed points to functional heterogeneity even within anatomically defined DA clusters. Recognizing the need for a systematic classification scheme, several groups have used single-cell profiling to catalog DA neurons based on their gene expression profiles. We aim here not only to synthesize points of congruence but also to highlight key differences between the molecular classification schemes derived from these studies. In doing so, we hope to provide a common framework that will facilitate investigations into the functions of DA neuron subtypes in the healthy and diseased brain.
机译:功能障碍多巴胺(DA)信号传导与广谱的神经精神疾病有关,促使调查中脑达神经元异质性如何巩固这种行为症状。 即使在解剖学定义的DA簇内,新兴文献实际上是功能异质性。 认识到需要一种系统分类方案,几组基于其基因表达谱使用单细胞分析到目录DA神经元。 我们的目标不仅是合成一致性的点,而且还突出了来自这些研究的分子分类方案之间的关键差异。 在这样做时,我们希望提供一个共同的框架,可促进对健康和患病的大脑中Da神经元亚型的功能的调查。

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