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首页> 外文期刊>Vascular and endovascular surgery >Systematic Review and Meta-Analysis of Drug-Eluting Balloon and Stent for Infrapopliteal Artery Revascularization
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Systematic Review and Meta-Analysis of Drug-Eluting Balloon and Stent for Infrapopliteal Artery Revascularization

机译：对药物洗脱球囊的系统评价和荟萃分析，用于侵占性动脉血运重建

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摘要

Background: Drug-eluting balloon (DEB) and drug-eluting stent (DES) have been proposed for the treatment of infrapopliteal artery disease. We performed a systematic review and meta-analysis of the current available studies investigating outcomes of DEB and DES in the treatment of infrapopliteal artery disease. Methods: Multiple databases were systematically searched to identify studies investigating the outcomes of DEB and DES in the treatment of patients with infrapopliteal artery disease. The quality of studies was assessed by Cochrane Collaboration method. The demographic data, risk factors, outcomes, and antiplatelet strategy were extracted. Results: Nine studies were identified with 707 and 606 patients in DEB/DES and standard percutaneous balloon angioplasty (PTA)/bare metal stenting (BMS) group, respectively. The risk of target lesion revascularization (TLR; odds ratio [OR] = 0.38, 95% confidence interval [CI]: 0.23-0.63, P <.01), restenosis rate (OR = 0.30, 95% CI: 0.18-0.50, P <.01), and amputation rate (OR = 0.49, 95% CI: 0.29-0.83, P <.01) significantly decreased in the DES group. The overall survival (OR = 0.86, 95% CI: 0.56-1.32, P =.50) was similar in DES and standard PTA/BMS group; TLR (OR = 0.59, 95% CI: 0.32-1.09, P =.09), restenosis rate (OR = 0.49, 95% CI: 0.11-2.14, P =.35), amputation rate (OR = 1.32, 95% CI: 0.51-3.40, P =.57), and overall survival (OR = 1.40, 95% CI: 0.72-2.71, P =.32) were similar in DEB and standard PTA group. Conclusion: The present meta-analysis suggests that compared with standard PTA/BMS, DES may decrease the risk of clinically driven TLR, restenosis rate, and amputation rate without any impact on mortality. However, DEB has no obvious advantage in the treatment of infrapopliteal disease. Due to the limitations of our study, more randomized controlled trials, especially those for DEB, are necessary.
机译：背景：已经提出了药物洗脱的气球（DEB）和药物洗脱支架（DES）用于治疗初始动脉疾病。我们对当前可用研究进行了系统审查和荟萃分析，调查了DEB和DES治疗侵扰性动脉疾病的结果。方法：系统地搜索多个数据库，以鉴定研究侵入侵占性动脉疾病患者的DEB和DES的研究。通过Cochrane合作方法评估研究质量。提取人口统计数据，危险因素，结果和抗血小板策略。结果：分别用707例和606名患者鉴定了九项研究，分别用DEB / DES和标准经皮球血管血管成形术（PTA）/裸机支架（BMS）组中的707例患者鉴定。靶病变血运重建的风险（TLR;差距[或] = 0.38,95％置信区间[CI]：0.23-0.63，P <.01），再生率（或= 0.30,95％CI：0.18-0.50， P <.01）和截肢率（或= 0.49,95％CI：0.29-0.83，P <.01）在DES组中显着降低。在DES和标准PTA / BMS组中，总存活（或= 0.86,95％CI：0.56-1.32，P = .50）; TLR（或= 0.59,95％CI：0.32-1.09，P = .09），再狭窄率（或= 0.49,95％CI：0.11-2.14，P = .35），截肢率（或= 1.32,95％ CI：0.51-3.40，p = .57）和总存活（或= 1.40,95％CI：0.72-2.71，P = .32）在DEB和标准PTA组中相似。结论：目前的荟萃分析表明，与标准PTA / BMS相比，DES可能会降低临床驱动的TLR，再狭窄率和截肢率的风险，而不会影响死亡率。然而，DEB在治疗侵扰性疾病方面没有明显的优势。由于我们的研究的局限性，需要更多随机对照试验，特别是DEB的对照试验。

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  • 来源
    《Vascular and endovascular surgery》 |2017年第2期|共12页
  • 作者

    Zhang Jianbin; Xu Xiaojie; Kong Jie; Xu Rongwei; Fan Xueqiang; Chen Jie; Zheng Xia; Ma Bo; Sun Mingsheng; Ye Zhidong; Liu Peng;

  • 作者单位

    China Japan Friendship Hosp Dept Cardiovasc Surg 2 Yinghua East Rd Beijing 100029 Peoples R;

    Chinese Acad Med Sci Peking Union Med Coll Grad Sch Beijing Peoples R China;

    China Japan Friendship Hosp Dept Cardiovasc Surg 2 Yinghua East Rd Beijing 100029 Peoples R;

    China Japan Friendship Hosp Dept Cardiovasc Surg 2 Yinghua East Rd Beijing 100029 Peoples R;

    China Japan Friendship Hosp Dept Cardiovasc Surg 2 Yinghua East Rd Beijing 100029 Peoples R;

    China Japan Friendship Hosp Dept Cardiovasc Surg 2 Yinghua East Rd Beijing 100029 Peoples R;

    China Japan Friendship Hosp Dept Cardiovasc Surg 2 Yinghua East Rd Beijing 100029 Peoples R;

    China Japan Friendship Hosp Dept Cardiovasc Surg 2 Yinghua East Rd Beijing 100029 Peoples R;

    China Japan Friendship Hosp Dept Cardiovasc Surg 2 Yinghua East Rd Beijing 100029 Peoples R;

    China Japan Friendship Hosp Dept Cardiovasc Surg 2 Yinghua East Rd Beijing 100029 Peoples R;

    China Japan Friendship Hosp Dept Cardiovasc Surg 2 Yinghua East Rd Beijing 100029 Peoples R;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 心脏血管和淋巴系外科学;
  • 关键词

    drug-eluting balloon; drug-eluting stent; infrapopliteal artery;

    机译：药物洗脱球囊;药物洗脱支架;侵入式动脉;

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