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首页> 外文期刊>Veterinary Parasitology >IgG avidity index and complete blood count as biomarkers of clinical disease in naturally infected dogs with Leishmania infantum
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IgG avidity index and complete blood count as biomarkers of clinical disease in naturally infected dogs with Leishmania infantum

机译：IgG亲和力指数和完全血统作为与Leishmania Infantum自然感染的狗的临床疾病生物标志物

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摘要

Canine visceral leishmaniosis (CVL), a parasitic disease caused by Leishmania infantum, may evolve to a chronic condition and lead to death. Evaluation of infected dogs is important to establish the clinical and laboratory parameters involved in the evolution of the disease. The objectives of the present study were to discriminate a canine population (n = 52) into sub-clinical and clinically affected dogs based on signs and scores, to evaluate the hematological, biochemical, histopathological and parasitological parameters of the two dog groups, and to analyze the results by multivariate regression analysis with the aim of establishing biomarkers of CVL clinical disease. The most common signs observed in the clinically affected dogs (n = 29) were hyperkeratosis, weight loss, onychogryphosis, pale mucosa and lymphadenomegaly. In the multivariate analysis, animals presenting high IgG avidity index and low red blood, lymphocyte and eosinophil counts, and low serum urea concentration had an increased probability of being classified as clinically affected (p & 0.05). All five parameters were considered to be strong biomarkers for monitoring the clinical disease, while IgG avidity percentage was strongly correlated with the number of clinical signs and could function as an indicator of the duration of infection. This is the first report on the application of IgG avidity and of multivariate regression analysis in establishing associations between the clinical signs of CVL and host biomarkers. Since avidity index (Al) percentages were strongly correlated with the number of clinical signs, it could be useful in clinical practice for auxiliary diagnosis of CVL and monitoring disease progression. A limitation of this study is the lack of information on co-infections by Anaplasma platys, Babesia conic vogeli, Ehrlichia canis and Hepatozoon conic. Therefore future studies should evaluate the influence of such co-infections on the associations studied using multivariate methods with larger samples.
机译：犬内脏Leishmaniosis（CVL）是由Leishmania Infantum引起的寄生疾病，可能会发展到慢性病症并导致死亡。感染犬的评估对于建立涉及疾病演变的临床和实验室参数非常重要。本研究的目的是基于迹象和评分将犬群（n = 52）区分成亚临床和临床影响的犬，以评估两只狗组的血液学，生化，组织病理学和寄生虫学参数，以及通过建立CVL临床疾病的生物标志物来分析多元回归分析结果。在临床影响的狗（n = 29）中观察到的最常见的迹象是高曲目，减肥，onychogryhyshos，苍白的粘膜和淋巴结肿大。在多变量分析中，呈现高IgG亲和力指数和低红血，淋巴细胞和嗜酸性粒细胞计数的动物，以及低血清尿素浓度在临床上受到归类的概率增加（P＆amp; 0.05）。所有五个参数被认为是强烈的生物标志物，用于监测临床疾病，而IgG Andity百分比与临床症状的数量强烈相关，并且可以作为感染持续时间的指标。这是关于IgG亲密和多元回归分析在建立CVL和宿主生物标志物的临床症状之间的关联中的第一个报告。由于耐酸性指数（Al）百分比与临床符号的数量强烈相关，因此在CV1的辅助诊断和监测疾病进展中可能有用。本研究的局限性是缺乏关于Anaplasma Platys，Babesia圆锥植物，ehrlichia canis和epopatozoon圆锥癌的相关信息。因此，未来的研究应该评估这种共感染对使用具有较大样品的多元方法研究的关联的影响。

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