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首页> 外文期刊>Vlaams Diergeneeskundig Tijdschrift >MRI-based morphometric analysis in relation to Chiari-like malformation in brachycephalic canine breeds
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MRI-based morphometric analysis in relation to Chiari-like malformation in brachycephalic canine breeds

机译：基于MRI的形态学分析与Chiari样禽类禽类种类的晶状体畸形

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摘要

The aim of this study was to investigate potential differences and correlations between brain and skull morphology and the clinical signs of brachycephalic dogs with and without Chiari-like malformation (CLM). Various measurements were derived from magnetic resonance images of the brain and craniocervical junction of thirty brachycephalic dogs in a flexed-neck position. Each dog was assigned a clinical grade. The distance from the planum of the foramen magnum to the pons was significantly reduced, providing evidence of craniocephalic disproportion similar to human patients with Chiari malformation type I. Cerebral length relative to cranial length was significantly increased in dogs with CLM compared with control dogs, supporting the hypothesis that CLM is governed by a global overcrowding of the brain, dissimilar to the human condition. Significant correlations were identified between these measurements and the extent of cerebellar herniation. No significant differences or correlations were identified with clinical grade. This is the first described morphometric analysis to use a strictly brachycephalic study population inclusive of a control group free from CLM.
机译：本研究的目的是探讨脑和头骨形态与带有和没有Chiari的畸形（CLM）之间的胸骨脑犬的临床症状的潜在差异和相关性。在弯曲颈部位置的脑脑和颅脑交界处的磁共振图像和颅脑连接的磁共振图像中得出各种测量。每只狗被分配临床等级。距离孔的Palsum的距离显着减少，提供了与人类畸形患者相似的颅骨歧视患者的迹象。与对照犬的CLM的狗，相对于颅长的脑长度显着增加，与对照犬相比，患者显着增加CLM的假设受到大脑的全球性过度拥挤，与人类状况不相似。在这些测量和小脑疝之间的程度之间鉴定了显着的相关性。临床等级没有鉴定显着的差异或相关性。这是第一次使用严格的短腹研究群体，包括不含CLM的对照组的严格胸腺研究人群。

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