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首页> 外文期刊>Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society >Therapeutic efficacy of early photobiomodulation therapy on the zones of stasis in burns: An experimental rat model study
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Therapeutic efficacy of early photobiomodulation therapy on the zones of stasis in burns: An experimental rat model study

机译：早期光致调节治疗对烧伤瘀滞区的治疗疗效：实验大鼠模型研究

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摘要

This study aimed to investigate the role of photobiomodulation therapy in preventing zones of stasis in burn wounds. We hypothesized that photobiomodulation therapy could promote tissue formation and release of nitric oxide (NO), and reduce inflammatory responses, thereby dilating local microvessels, reducing necrosis and apoptosis. Thirty rats were randomly divided into control group (CG) and laser group (LG). The zone of stasis was formed by applying a brass comb to the skin resulting in four rectangular burns separated by three unburned interspaces. The left side was laser wound (LW), while the right side was shielded wound (SW). The LW of LG was immediately subjected to photobiomodulation therapy, followed by once-daily 30-minutes photobiomodulation therapy sessions. Skin ultrasound and Doppler angiography analyses were used to evaluate the statuses of the zones of stasis at 1, 24, and 96 hours after injury. Harvested burn wound tissue was subjected to hematoxylin-eosin staining and HMGB1, caspase 3, and thrombomodulin immunohistochemistry, and the contents of NO and TNF-alpha were measured in stasis tissue. Thrombomodulin, HMGB1, and caspase 3 immunohistochemistry revealed significantly lower positive staining rates in the LW of LG rats relative to the others at 96 hours (p 0.05), as well as a significantly higher skin blood flow relative to the others (p 0.05). The NO content was significantly higher in the LW of LG, compared with other wounds, at 24 and 96 hours after injury (p 0.05). The TNF-alpha level was significantly lower in the LW of LG than in other wounds at 96 hours (p 0.05). Early, local photobiomodulation therapy can effectively ameliorate injury progression in the zone of stasis. However, these beneficial effects are limited to the directly irradiated sites.
机译：本研究旨在探讨光生命调节治疗在预防烧伤伤口中瘀滞区的作用。我们假设光生物调节治疗可以促进组织形成和释放一氧化氮（NO），并降低炎症反应，从而扩张局部微血管，降低坏死和凋亡。将30只大鼠随机分为对照组（CG）和激光组（LG）。通过将黄铜梳子施加到皮肤上形成塞体，导致四个未燃烧的间隙分开的四个矩形燃烧形成。左侧是激光伤口（LW），而右侧是屏蔽伤口（SW）。 LG的LG立即进行光生物调节治疗，然后进行一次每日30分钟的光致调节治疗疗程。皮肤超声和多普勒血管造影分析用于评估损伤后的1,24和96小时的静脉区域的状态。收获的烧伤缠绕组织受到苏木精 - 曙红染色和HMGB1，胱天蛋白酶3和血栓调节蛋白免疫组化，并且在椎板组织中测量NO和TNF-α的含量。血栓调节蛋白，HMGB1和Caspase 3免疫组织化学显示在96小时内相对于其他Lg大鼠Lg大鼠的LW中的阳性染色率显着降低（P <0.05），以及相对于其他的显着更高的皮肤血流（P＆lt。 ; 0.05）。 LG的LG没有含量明显高，与其他伤口相比，损伤后24和96小时（P <0.05）。在96小时的LG的LG中，TNF-α水平显着降低（P <0.05）。早期，局部光致调节治疗可以有效地改善瘀滞区域的损伤进展。然而，这些有益效果仅限于直接辐照的位点。

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