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Exploring Multiplicity Conditions in Enzymatic Reaction Networks

机译:在酶反应网络中探索多重性条件

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In this work,a novel algorithmic approach to detect multiplicity of steady states in enzymatic reaction networks is presented. The method exploits the structural properties of networks derived from the Chemical Reaction Network Theory. In first instance,the space of parameters is divided in different regions according to the qualitative behavior induced by the parameters in the long term dynamics of the network. Once the regions are identified,a condition for the appearance of multiplicities is checked in the different regions by solving a given optimization problem. In this way,the method allows the characterization of the whole parameter space of biochemical networks in terms of the appearance or not of multistability. The approach is illustrated through a well-known case of enzymatic catalysis with substrate inhibition.
机译:在这项工作中,提出了一种新颖的算法方法来检测酶反应网络中的稳态。该方法利用了源自化学反应网络理论的网络的结构特性。首先,根据参数在网络的长期动态中引起的定性行为,将参数的空间划分为不同的区域。一旦确定了区域,则通过解决给定的优化问题,在多个区域中检查出现多重性的条件。以此方式,该方法允许根据外观的稳定性或不具有多重稳定性来表征生化网络的整个参数空间。通过众所周知的具有底物抑制作用的酶催化案例说明了该方法。

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