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首页> 外文期刊>Human brain mapping >Exploring the advantages of multiband fMRI with simultaneous EEG to investigate coupling between gamma frequency neural activity and the BOLD response in humans
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Exploring the advantages of multiband fMRI with simultaneous EEG to investigate coupling between gamma frequency neural activity and the BOLD response in humans

机译：用同时脑电图探讨多频FMRI的优势，探讨伽马频率神经活动与人类大胆反应的耦合

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Abstract We established an optimal combination of EEG recording during sparse multiband (MB) fMRI that preserves high‐resolution, whole‐brain fMRI coverage while enabling broad‐band EEG recordings which are uncorrupted by MRI gradient artefacts (GAs). We first determined the safety of simultaneous EEG recording during MB fMRI. Application of MB factor?=?4 produced 1°C peak heating of electrode/hardware during 20?min of GE‐EPI data acquisition. However, higher SAR sequences require specific safety testing, with greater heating observed using PCASL with MB factor?=?4. Heating was greatest in the electrocardiogram channel, likely due to it possessing longest lead length. We investigated the effect of MB factor on the temporal signal‐to‐noise ratio for a range of GE‐EPI sequences (varying MB factor and temporal interval between slice acquisitions). We found that, for our experimental purpose, the optimal acquisition was achieved with MB factor?=?3, 3mm isotropic voxels, and 33 slices providing whole head coverage. This sequence afforded a 2.25?s duration quiet period (without GAs) in every 3?s TR. Using this sequence, we demonstrated the ability to record gamma frequency (55–80?Hz) EEG oscillations, in response to right index finger abduction, that are usually obscured by GAs during continuous fMRI data acquisition. In this novel application of EEG‐MB fMRI to a motor task, we observed a positive correlation between gamma and BOLD responses in bilateral motor regions. These findings support and extend previous work regarding coupling between neural and hemodynamic measures of brain activity in humans and showcase the utility of EEG‐MB fMRI for future investigations.
机译：摘要建立了脑电图记录的过程中稀疏多频带（MB）功能磁共振成像的最佳组合，同时实现宽带脑电图记录其是通过MRI梯度文物（气）廉洁蜜饯高分辨率，全脑功能磁共振成像覆盖。我们首先MB功能磁共振成像过程中确定同时脑电图记录的安全性。 MB因子的应用= 4产生＆LT;？？20 GE-EPI数据采集分钟期间电极/硬件的1℃峰加热。然而，较高的SAR序列需要特定的安全检测，以更大的加热使用PCASL与MB因子α=？4观察到。暖气是最大的在心电图通道，可能是由于它拥有最长的引线长度。我们研究了MB因子的所述时间信噪比的效果为一系列GE-EPI序列（变化MB因子和切片采集之间的时间间隔）的。我们发现，在我们的实验目的，最佳的采集以MB因素实现？=？3的3mm各向同性体素，以及33片提供整个头部覆盖。该序列提供每3？的TR 2.25？的持续时间静默期（不含气体）。使用此序列，我们证明响应于右手食指外展的能力记录伽马频率（55-80？赫兹）EEG振荡，即通常通过气相连续fMRI数据采集期间遮蔽。在这部小说中EEG-fMRI的MB的应用于电机的任务，我们在双侧运动区观察到伽玛和BOLD响应之间的正相关关系。这些研究结果支持和扩展有关人类大脑活动的神经和血液动力学的措施之间的耦合以前的工作和展示EEG-fMRI的MB为今后的调查的效用。

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