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首页> 外文期刊>Alcohol >Abamectin attenuates gastric mucosal damage induced by ethanol through activation of vagus nerve in rats.
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Abamectin attenuates gastric mucosal damage induced by ethanol through activation of vagus nerve in rats.

机译：阿维菌素通过激活迷走神经减轻乙醇引起的胃粘膜损伤。

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摘要

Some type A gamma-aminobutyric acid (GABA(A)) receptor agonists are effective in protecting against the formation of stomach lesions induced by ethanol. Natural product abamectin, one of the existing GABA(A) receptor agonists, might protect against the development of gastric ulcers induced by ethanol. We investigated the protective effect of abamectin against the formation of gastric mucosal lesions induced by ethanol in rats. Abamectin (3 mg/kg, p.o.) was given to rats 1 h before administration of ethanol [4 ml of a 30% (volume/volume) solution]. Mucosal lipid peroxidation (LPO), nitric oxide (NO) levels, and ulcer index were measured 3 h after gastric surgery (vagotomy vs. sham vagotomy) in treated versus control subjects. Abamectin attenuated ethanol-induced gastric ulceration, decreased LPO regeneration, and increased NO production in the gastric mucosa of rats in the sham vagotomy group. However, this protective effect of abamectin against ethanol-induced gastric lesions was not observed in rats in the group that underwent vagotomy. These results support the suggestion that administration of abamectin ameliorated the ethanol-induced gastric mucosal injury through elevation of NO production. Activation of the vagus nerve may be involved in the abamectin-associated gastric protection against the effects of ethanol in rats.
机译：某些A型γ-氨基丁酸（GABA（A））受体激动剂可有效防止乙醇诱导的胃部病变的形成。天然产物阿维菌素是现有的GABA（A）受体激动剂之一，可能可以防止乙醇诱导的胃溃疡的发展。我们调查了阿维菌素对乙醇诱导的大鼠胃黏膜损伤形成的保护作用。在给予乙醇[4 ml的30％（体积/体积）溶液]前1小时，给大鼠服用阿维菌素（3 mg / kg，口服）。在胃手术（迷走神经切断术与假迷走神经切断术）后3小时，对接受治疗的人和对照组进行了粘膜脂质过氧化（LPO），一氧化氮（NO）水平和溃疡指数的测量。在假迷走神经切断组，阿维菌素可减轻乙醇引起的胃溃疡，降低LPO再生，并增加大鼠胃黏膜中NO的产生。但是，在进行迷走神经切断术的组中，未观察到阿维菌素对乙醇诱发的胃部损伤的这种保护作用。这些结果支持以下建议：通过增加NO的产生，阿维菌素的施用改善了乙醇诱导的胃粘膜损伤。迷走神经的激活可能参与了阿维菌素相关的胃对大鼠乙醇的保护作用。

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