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Operant ethanol self-administration in ethanol dependent mice

机译:乙醇依赖小鼠的操作性乙醇自我给药

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摘要

While rats have been predominantly used to study operant ethanol self-administration behavior in the context of dependence, several studies have employed operant conditioning procedures to examine changes in ethanol self-administration behavior as a function of chronic ethanol exposure and withdrawal experience in mice. This review highlights some of the advantages of using operant conditioning procedures for examining the motivational effects of ethanol in animals with a history of dependence. As reported in rats, studies using various operant conditioning procedures in mice have demonstrated significant escalation of ethanol self-administration behavior in mice rendered dependent via forced chronic ethanol exposure in comparison to nondependent mice. This paper also presents a summary of these findings, as well as suggestions for future studies.
机译:尽管大鼠主要用于研究依赖环境下的乙醇自我管理行为,但有几项研究采用了操作条件程序来检查乙醇自我管理行为的变化与小鼠慢性乙醇暴露和戒断经验的关系。这篇综述强调了使用操作性条件调节程序检查乙醇对有依赖史的动物的激励作用的一些优势。如在大鼠中所报道的,在小鼠中使用各种操作性调节程序的研究表明,与非依赖型小鼠相比,在通过强迫慢性乙醇暴露而依赖的小鼠中,乙醇自我给药行为的显着升高。本文还提供了这些发现的摘要,以及对未来研究的建议。

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