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首页> 外文期刊>Zeitschrift fur Arznei- und Gewurzpflanzen >Association between Asian dust exposure and respiratory function in children with bronchial asthma in Nagasaki Prefecture, Japan
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Association between Asian dust exposure and respiratory function in children with bronchial asthma in Nagasaki Prefecture, Japan

机译：日本长崎县支气管哮喘儿童亚洲粉尘接触与呼吸功能的关联

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Background Studies on the adverse effects of Asian dust (AD) on respiratory function in children are scarce. The objective of this study was to examine the association between AD and respiratory function by measuring peak expiratory flow rates (PEFRs) in asthmatic children. Methods The study was carried out from March to May from 2014 through 2016. One hundred ten children with bronchial asthma were recruited from four hospitals in the Goto Islands and south Nagasaki area in Nagasaki prefecture. The parents were asked to record their children's PEFRs every morning/evening and clinical symptoms in an asthma diary. AD was assessed from light detection and ranging data, and a linear mixed-effects model was used to estimate the effects of AD on daily PEFR. Time-stratified case-crossover analyses were performed to examine the association between AD and asthma attacks defined by reduction levels in PEFR. Results AD was detected on 11 days in the Goto Islands, and on 23 days in the south Nagasaki area. After adjusting for age, sex, temperature, and daily oxidants, we found a consistent association between AD and a 1.1% to 1.7% decrease in PEFR in the mornings and a 0.7% to 1.3% decrease in the evenings at a lag of 0 to 5 days. AD was not associated with the number of asthma attacks, respiratory symptoms, or other symptoms at any lag days examined. Conclusions Exposure to AD was associated with reduced PEFR, although the effects were not large enough to induce clinically apparent symptoms, in clinically well-controlled asthmatic children.
机译：背景技术亚洲粉尘（AD）对儿童呼吸功能的不利影响的研究是稀缺的。本研究的目的是通过测量哮喘儿童中的峰值呼气流量（PEFRS）来检查AD和呼吸功能之间的关联。方法本研究于2014年至2016年至5月至5月至2016年进行。从长崎县的Goto群岛和南长崎地区的四家医院招募了一百十个带支气管哮喘的儿童。父母被要求每天早上/晚上录制孩子的PEFR，哮喘日记中的临床症状。从光检测和测距数据评估广告，并使用线性混合效应模型来估计广告对日常PEFR的影响。进行时间分层壳体交叉分析，以检查通过PEFR中减少水平定义的AD和哮喘攻击之间的关联。结果广告于Goto群岛11天内检测到，并在南长崎地区23天。调整年龄，性别，温度和日常氧化剂后，我们发现AD之间的一致关联和早晨的PEFR减少1.1％至1.7％，夜晚减少0.7％至1.3％，滞后为0至5天。在检查的任何滞后日，AD与哮喘发作，呼吸系统症状或其他症状的数量无关。结论暴露于AD与减少的PEFR相关，尽管在临床上良好控制的哮喘儿童中，其效果足以诱导临床表观症状。

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