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首页> 外文期刊>Alcohol >Relation between plasma brain-derived neurotrophic factor and nerve growth factor in the male patients with alcohol dependence.
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Relation between plasma brain-derived neurotrophic factor and nerve growth factor in the male patients with alcohol dependence.

机译：酒精依赖男性患者血浆脑源性神经营养因子与神经生长因子的关系。

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摘要

Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are thought to be related to neuroprotection in cell culture and animal studies. Our aim was to verify the changes in human plasma BDNF and NGF concentrations induced by chronic alcohol use. Forty-one male patients with alcohol dependence were sampled the next morning of admission and compared with 41 healthy male subjects. Plasma BDNF and NGF were assayed using an enzyme-linked immunosorbent assay (ELISA). Mean plasma BDNF level was significantly higher in the patients with alcohol dependence (3502.21+/-1726.9 pg/mL) compared with the healthy subjects (861.75+/-478.9 pg/mL) (P=.000). Mean plasma NGF level was also significantly higher in patients with alcohol dependence (137.64+/-32.7 pg/mL) than in healthy subjects (112.61+/-90.2 pg/mL) (P=.012). Plasma BDNF and NGF levels showed significant negative correlation in alcohol dependence group (r=-0.388, P=.012). Increased plasma BDNF and NGF with negative correlation in alcohol-dependent patients may have some role in the regeneration of damage done by chronic alcohol use.
机译：在细胞培养和动物研究中，脑源性神经营养因子（BDNF）和神经生长因子（NGF）被认为与神经保护有关。我们的目的是验证长期饮酒引起的人血浆BDNF和NGF浓度的变化。入院第二天早晨对41名酒精依赖的男性患者进行了采样，并与41名健康男性受试者进行了比较。使用酶联免疫吸附测定（ELISA）测定血浆BDNF和NGF。酒精依赖患者的平均血浆BDNF水平显着高于健康受试者（861.75 +/- 478.9 pg / mL）（3502.21 +/- 1726.9 pg / mL）（P = .000）。酒精依赖患者的平均血浆NGF水平也显着高于健康受试者（137.64 +/- 32.7 pg / mL）（112.61 +/- 90.2 pg / mL）（P = .012）。酒精依赖组血浆BDNF和NGF水平呈显着负相关（r = -0.388，P = .012）。酒精依赖型患者血浆BDNF和NGF的升高与负相关可能在慢性饮酒造成的损伤的再生中起一定作用。

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