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首页> 外文期刊>Alcohol >Effects of alcohol and saccharin deprivations on concurrent ethanol and saccharin operant self-administration by alcohol-preferring (P) rats.
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Effects of alcohol and saccharin deprivations on concurrent ethanol and saccharin operant self-administration by alcohol-preferring (P) rats.

机译：酒精和糖精剥夺对酒精偏爱（P）大鼠同时进行的乙醇和糖精操作性自我给药的影响。

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摘要

Consumption of sweet solutions has been associated with a reduction in withdrawal symptoms and alcohol craving in humans. The objective of the present study was to determine the effects of ethanol and saccharin (SACC) deprivations on operant oral self-administration. Alcohol-preferring (P) rats were allowed to lever press concurrently self-administer ethanol (15% vol/vol) and SACC (0.0125% g/vol) for 8 weeks. Rats were then maintained on daily operant access (nondeprived), deprived of both fluids (2 weeks), deprived of SACC and given 2 ml of ethanol daily, or deprived of ethanol and given 2 ml of SACC daily. All groups were then given 2 weeks of daily operant access to ethanol and SACC, followed by an identical second deprivation period. P rats responded more for ethanol than SACC. All deprived groups increased responding on the ethanol lever, but not on the SACC lever. Daily consumption of 2 ml ethanol decreased the duration of the alcohol deprivation effect (ADE). Home cage access to 2 ml of SACC also decreased the ADE but to a lesser extent than access to ethanol. A second deprivation period further increased and prolonged the expression of an ADE. These results show ethanol is a more salient reinforcer than SACC. With concurrent access to ethanol and SACC, P rats do not display a saccharin deprivation effect. Depriving P rats of both ethanol and SACC had the most pronounced effect on the magnitude and duration of the ADE, suggesting that there may be some interactions between ethanol and SACC in their CNS reinforcing effects.
机译：食用甜味剂与减少人的戒断症状和饮酒有关。本研究的目的是确定乙醇和糖精（SACC）剥夺对手术口服自我给药的影响。允许偏爱酒精（P）的大鼠同时自我压榨乙醇（15％vol / vol）和SACC（0.0125％g / vol）8周。然后将大鼠维持每日手术访问（不剥夺），剥夺两种液体（2周），剥夺SACC并每天给予2 ml乙醇，或剥夺乙醇并每天2 ml给予SACC。然后给所有组每日手术2周，以使用乙醇和SACC，然后进行相同的第二次剥夺期。 P大鼠对乙醇的反应比SACC多。所有被剥夺的群体对乙醇杠杆的反应有所增加，但对SACC杠杆的反应却没有。每天消耗2 ml乙醇会减少酒精剥夺效应（ADE）的持续时间。家笼接触2 ml SACC也会降低ADE，但程度要比接触乙醇小。第二个剥夺期进一步增加并延长了ADE的表达。这些结果表明，乙醇比SACC具有更显着的增强作用。在同时使用乙醇和SACC的情况下，P大鼠没有糖精剥夺作用。剥夺P大鼠的乙醇和SACC对ADE的大小和持续时间的影响最明显，这表明乙醇和SACC在CNS增强作用中可能存在一些相互作用。

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